Toxic epidermal necrolysis (TEN) is a life-threatening, typically drug-induced,
mucocutaneous disease. TEN has a high mortality rate, making early diagnosis and …

Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a rather distinct
severe adverse drug reaction characterised by skin rash, fever, lymph node enlargement …

Objectives: The aims of this review are to summarize the definitions, causes, and clinical
course as well as the current understanding of the genetic background, mechanism of …

Toxic epidermal necrolysis (TEN) is a severe cutaneous drug reaction with a mortality rate of
approximately 30%. The hallmark of TEN is widespread epidermal sloughing due to …

The glycocalyx surrounds every eukaryotic cell and is a complex mesh of proteins and
carbohydrates. It consists of proteoglycans with glycosaminoglycan side chains, which are …

Erythema multiforme (EM) and related disorders comprise a group of mucocutaneous
disorders characterized by variable degrees of mucosal and cutaneous blistering and …

N‑acetylcysteine is a mucolytic drug which is commonly used as an antidote for
acetaminophen toxicity. It is a thiol compound, which acts as a donor of cysteine, leading to …

Clinically, erythema multiforme involves macular, papular or urticarial lesions, as well as the
classical iris or 'target lesions', distributed preferentially on the distal extremities. Lesions …

Abstract Purpose of Study Immune-mediated adverse drug reactions occur commonly in
clinical practice and include mild, self-limited cutaneous eruptions, IgE-mediated …

Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe
cutaneous reactions that are medication‐induced in most instances. While the clinical …