Immunotherapy has revolutionized the treatment of patients with cancer. However,
promoting antitumour immunity in patients with tumours that are resistant to these therapies …

Mammalian genes were long thought to be constrained within somatic cells in most cell
types. This concept was challenged recently when cellular organelles including …

Postsurgical treatment of glioblastoma multiforme (GBM) by systemic chemotherapy and
radiotherapy is often inefficient. Tumor cells infiltrating deeply into the brain parenchyma are …

Mesenchymal stem cells (MSCs) are regarded as highly promising cells for allogeneic cell
therapy, owing to their multipotent nature and ability to display potent and varied functions in …

Glioblastoma is the most aggressive primary brain tumor with a poor prognosis. The 2021
WHO CNS5 classification has further stressed the importance of molecular signatures in …

Glioblastoma is one of the most aggressive central nervous system malignancies with high
morbidity and mortality. Current clinical approaches, including surgical resection …

Small extracellular vesicles (SEVs) are extracellular vesicles containing DNA, RNA, and
proteins and are involved in intercellular communication and function, playing an essential …

Since the discovery of ferroptosis, it has been postulated that this type of cell death could be
utilized in treatments for cancer. Unfortunately, several highly aggressive tumor models are …

Local drug delivery has become an effective method for disease therapy in fine organs
including ears, eyes, and noses. However, the multiple anatomical and physiological …

Glioblastoma (GBM) is the most common lethal primary brain cancer in adults. Despite
treatment regimens including surgical resection, radiotherapy, and temozolomide (TMZ) …