Aporphines: A privileged scaffold in CNS drug discovery

R Zhu, G Jiang, W Tang, X Zhao, F Chen… - European Journal of …, 2023 - Elsevier
Aporphine alkaloids embedded in 4H-dibenzo [de, g] quinoline four-ring structures belong to
one of the largest subclasses of isoquinoline alkaloids. Aporphine is a privileged scaffold in …

[HTML][HTML] Putting the brakes on tumorigenesis with natural products of plant origin: insights into the molecular mechanisms of actions and immune targets for bladder …

Q Wu, JPC Wong, HF Kwok - Cells, 2020 - mdpi.com
Bladder cancer is the 10th most commonly diagnosed cancer worldwide. Although the
incidence in men is 4 times higher than that in women, the diagnoses are worse for women …

[HTML][HTML] Protopine triggers apoptosis via the intrinsic pathway and regulation of ROS/PI3K/Akt signalling pathway in liver carcinoma

C Nie, B Wang, B Wang, N Lv, R Yu, E Zhang - Cancer Cell International, 2021 - Springer
Background Protopine is an isoquinoline alkaloid that possesses various biological activities
including the anti-tumour activity. However, the effects of protopine on liver carcinoma cells …

[HTML][HTML] Alkaloid and acetogenin-rich fraction from Annona crassiflora fruit peel inhibits proliferation and migration of human liver cancer HepG2 cells

AB Justino, RM Florentino, A França, ACML Filho… - PLoS …, 2021 - journals.plos.org
Plant species from Annonaceae are commonly used in traditional medicine to treat various
cancer types. This study aimed to investigate the antiproliferative potential of an alkaloid and …

Non-volatile constituents from Monimiaceae, Siparunaceae and Atherospermataceae plant species and their bioactivities: An up-date covering 2000–2021

O El Mahdi, A Ouakil, M Lachkar - Phytochemistry, 2022 - Elsevier
Abstractika The Monimiaceae, Siparunaceae, and Atherospermataceae, formerly included
in the broad ''old''Monimiaceae family, have long been known for their uses in traditional …

[HTML][HTML] 8-, 9-, and 11-Aryloxy dimeric aporphines and their pharmacological activities

G Ali, GD Cuny - Molecules, 2021 - mdpi.com
Aporphines, a major group of aporphinoid alkaloids, exhibit interesting and diverse
pharmacological activities. A set of dimeric aporphines with an aryloxy group at C8, C9, and …

[HTML][HTML] Comprehensive Tools of Alkaloid/Volatile Compounds–Metabolomics and DNA Profiles: Bioassay-Role-Guided Differentiation Process of Six Annona sp …

MA Mohammed, N Elzefzafy, MF El-Khadragy… - Pharmaceuticals, 2024 - mdpi.com
Trees of the Annona species that grow in the tropics and subtropics contain compounds that
are highly valuable for pharmacological research and medication development and have …

Synthesis and biological activity of 2, 7-naphthyridine derivatives: An overview

A Wójcicka - Current Organic Chemistry, 2021 - ingentaconnect.com
2, 7-Naphthyridine is one of the six structural isomers of pyridopyridine. Biological
investigations have shown that these compounds have a broad spectrum of activity. They …

Cytotoxic Activity of Alkaloids Isolated from Stephania glandulifera Miers

J Dhungel, BP Marasini, E Manandhar… - Journal of Biologically …, 2023 - Taylor & Francis
From the caudex of Stephania glandulifera Miers, five alkaloids were isolated using a cold
percolation method with 90% methanol. The methanol extract was fractionated into three …

Therapeutic effect of natural compounds in targeting ROS-induced cancer

PK Raghav, Z Mann, V Krishnakumar… - Handbook of oxidative …, 2021 - Springer
Every cell within the body maintains homeostasis for the production of energy through
mitochondrial oxidation. This homeostasis is disturbed by high metabolic activity, mutations …