Profiling native pulmonary basement membrane stiffness using atomic force microscopy

B Hartmann, L Fleischhauer, M Nicolau, THL Jensen… - Nature protocols, 2024 - nature.com
Mammalian cells sense and react to the mechanics of their immediate microenvironment.
Therefore, the characterization of the biomechanical properties of tissues with high spatial …

[HTML][HTML] Enhanced Optic Nerve Expansion and Altered Ultrastructure of Elastic Fibers Induced by Lysyl Oxidase Inhibition in a Mouse Model of Marfan Syndrome

HJ Wu, E Krystofiak, J Kuchtey, RW Kuchtey - The American Journal of …, 2024 - Elsevier
Two major constituents of exfoliation material, fibrillin-1 and lysyl oxidase-like 1 (encoded by
FBN1 and LOXL1), are implicated in exfoliation glaucoma, yet their individual contributions …

Lack of evidence for GWAS signals of exfoliation glaucoma working via monogenic loss-of-function mutation in the nearest gene

KJ Meyer, JH Fingert… - Human molecular …, 2024 - academic.oup.com
Purpose: Exfoliation syndrome (XFS) is a systemic disease of elastin-rich tissues involving a
deposition of fibrillar exfoliative material (XFM) in the anterior chamber of the eye, which can …

[HTML][HTML] Collagen Mimetic Peptides Promote Repair of MMP-1-Damaged Collagen in the Rodent Sclera and Optic Nerve Head

GO Bou Ghanem, D Koktysh, RO Baratta… - International Journal of …, 2023 - mdpi.com
The structural and biomechanical properties of collagen-rich ocular tissues, such as the
sclera, are integral to ocular function. The degradation of collagen in such tissues is …

[HTML][HTML] IN SEARCH OF MOUSE MODELS FOR EXFOLIATION SYNDROME

RW Kuchtey, S Insignares, TS Yang… - American Journal of …, 2024 - Elsevier
Purpose Exfoliation syndrome (XFS) is a systemic connective tissue disorder with elusive
pathophysiology. We hypothesize that a mouse model with elastic fiber defects caused by …

Evaluation of Anterior Scleral Thickness and Angle Parameters in Eyes with Pseudoexfoliation Syndrome and Glaucoma

O Alpogan, Y Un, H Tekcan, AO Kose… - Journal of …, 2024 - journals.lww.com
Objective: To evaluate anterior scleral thickness (AST) in eyes with pseudoexfoliation (PX)
and to examine the relationship between AST and Schlemm's canal (SC), trabecular …