Applications of molecular imaging in cancer gene therapy

M Iyer, M Sato, M Johnson, SS Gambhir… - Current gene …, 2005 - ingentaconnect.com
Gene-based therapy is a promising and flexible therapeutic approach to manage diverse
types of cancer. The lack of convincing therapeutic success of current gene therapy …

Noninvasive optical tracking of red fluorescent protein-expressing cancer cells in a model of metastatic breast cancer

PT Winnard Jr, JB Kluth, V Raman - Neoplasia, 2006 - Elsevier
We have evaluated the use of the Xenogen IVIS 200 imaging system for real-time
fluorescence protein-based optical imaging of metastatic progression in live animals. We …

Imaging the modulation of adenoviral kinetics and biodistribution for cancer gene therapy

JD Mocanu, KW Yip, NM Alajez, W Shi, JH Li, SJ Lunt… - Molecular Therapy, 2007 - cell.com
See page 841 To explore systemic utilization of Epstein–Barr virus (EBV)-specific
transcriptionally targeted adenoviruses, three vectors were constructed to examine kinetics …

Compositions for the treatment of cancer, and methods for testing and using the same

SC Kachlany - US Patent 8,053,406, 2011 - Google Patents
(57) ABSTRACT A composition comprising leukotoxin proteins isolated from a bacterium is
provided. In this composition, greater than 85% of the leukotoxin proteins are chemically …

Integrated lymphography using fluorescence imaging and magnetic resonance imaging in intact mice

Y Inoue, Y Masutani, S Kiryu, T Haishi… - Molecular …, 2011 - journals.sagepub.com
We assessed lymph drainage in living mice by an integrated imaging method using
fluorescence imaging (FLI) and magnetic resonance imaging (MRI). Mice were …

Visualization of head and neck cancer models with a triple fusion reporter gene

Y Zheng, Q Lin, H Jin, J Chen… - Journal of Innovative …, 2012 - World Scientific
The development of experimental animal models for head and neck tumors generally rely on
the bioluminescence imaging to achieve the dynamic monitoring of the tumor growth and …

Integrated imaging approach to tumor model mice using bioluminescence imaging and magnetic resonance imaging

Y Inoue, Y Masutani, S Kiryu, T Haishi… - Molecular …, 2010 - journals.sagepub.com
We developed an integrated imaging method using bioluminescence imaging (BLI) and
magnetic resonance imaging (MRI) and applied it to mouse tumor monitoring. BLIs and …

Rapid assay to test anti-cancer drugs under physiological conditions

S Kachlany - US Patent App. 12/150,038, 2008 - Google Patents
GOIN 33/53(2006.01) Correspondence Address:(52) US Cl........................................................
435/721 University of Medicine and Dentistry of New Jersey (57) ABSTRACT Office of …

Compositions for the treatment of cancer, and methods for testing and using the same

CS Kachlany - US Patent App. 13/241,683, 2012 - Google Patents
(57) ABSTRACT A composition comprising leukotoxin proteins isolated from a bacterium is
provided. In this composition, greater than 85% of the leukotoxin proteins are chemically …

Compositions for the treatment of cancer, and methods for testing and using the same

SC Kachlany - US Patent App. 14/024,110, 2014 - Google Patents
(57) ABSTRACT A composition comprising leukotoxin proteins isolated from a bacterium is
provided. In this composition, greater than 85% of the leukotoxin proteins are chemically …