Virulence Factors of Pseudomonas Aeruginosa and Antivirulence Strategies to Combat Its Drug Resistance

C Liao, X Huang, Q Wang, D Yao, W Lu - Frontiers in cellular and …, 2022 - frontiersin.org
Pseudomonas aeruginosa is an opportunistic pathogen causing nosocomial infections in
severely ill and immunocompromised patients. Ubiquitously disseminated in the …

Ebselen and analogues: Pharmacological properties and synthetic strategies for their preparation

C Santi, C Scimmi, L Sancineto - Molecules, 2021 - mdpi.com
Ebselen is the leader of selenorganic compounds, and starting from its identification as
mimetic of the key antioxidant enzyme glutathione peroxidase, several papers have …

Regulation of biofilm exopolysaccharide production by cyclic di-guanosine monophosphate

MB Poulin, LL Kuperman - Frontiers in Microbiology, 2021 - frontiersin.org
Many bacterial species in nature possess the ability to transition into a sessile lifestyle and
aggregate into cohesive colonies, known as biofilms. Within a biofilm, bacterial cells are …

Repurposing high-throughput screening identifies unconventional drugs with antibacterial and antibiofilm activities against Pseudomonas aeruginosa under …

G Di Bonaventura, V Lupetti, A Di Giulio… - Microbiology …, 2023 - Am Soc Microbiol
Pseudomonas aeruginosa is the most common pathogen infecting cystic fibrosis (CF) lungs,
causing acute and chronic infections. Intrinsic and acquired antibiotic resistance allow P …

Advances in pulmonary drug delivery targeting microbial biofilms in respiratory diseases

A Sharma, D Kumar, K Dahiya, S Hawthorne… - …, 2021 - Taylor & Francis
The increasing burden of respiratory diseases caused by microbial infections poses an
immense threat to global health. This review focuses on the various types of biofilms that …

Antibacterial activity of ebselen

M Maślanka, A Mucha - International Journal of Molecular Sciences, 2023 - mdpi.com
Ebselen is a low-molecular-weight organoselenium compound that has been broadly
studied for its antioxidant, anti-inflammatory, and cytoprotective properties. These …

Ebselen: A Promising Repurposing Drug to Treat Infections Caused by Multidrug‐Resistant Microorganisms

A Alves de Lima e Silva… - … Perspectives on Infectious …, 2024 - Wiley Online Library
Bacterial multiresistance to drugs is a rapidly growing global phenomenon. New resistance
mechanisms have been described in different bacterial pathogens, threatening the effective …

Ebselen: A Review on its Synthesis, Derivatives, Anticancer Efficacy and Utility in Combating SARS-COV-2

F Ali, S Alom, SR Ali, B Kondoli, P Sadhu… - Mini Reviews in …, 2024 - ingentaconnect.com
Ebselen is a selenoorganic chiral compound with antioxidant properties comparable to
glutathione peroxidase. It is also known as 2-phenyl-1, 2-benzisoselenazol-3 (2H)-one. In …

Biofilm inhibition/eradication: exploring strategies and confronting challenges in combatting biofilm

A Srivastava, N Verma, V Kumar, P Apoorva… - Archives of …, 2024 - Springer
Biofilms are complex communities of microorganisms enclosed in a self-produced
extracellular matrix, posing a significant threat to different sectors, including healthcare and …

Sterically hindered phenolic derivatives: effect on the production of Pseudomonas aeruginosa virulence factors, high-throughput virtual screening and ADME …

MY Gvozdev, IS Turomsha, VV Savich… - Archives of …, 2024 - Springer
Inhibition of quorum sensing is considered to be an effective strategy of control and
treatment of a wide range of acute and persistent infections. Pseudomonas aeruginosa is an …