Abstract (C–X–C motif) ligand (CXCL) 10 (CXCL10) belongs to the ELR− CXC subfamily
chemokine. CXCL10 exerts its function through binding to chemokine (C–X–C motif) …

Scleroderma renal crisis (SRC) is a rare, potentially life-threatening complication that affects
2–15% of patients with systemic sclerosis (SSc, also known as scleroderma). SRC typically …

Background The treatment of systemic sclerosis (SSc) represents a great clinical challenge
because of the complex disease pathogenesis including vascular, fibrotic, and immune T …

Abstract Introduction Systemic sclerosis (SSc) has complex pathogenesis and likely
multifactorial causes. Environmental exposures have been suggested to play a role in SSc …

The clinical spectrum and prognosis of systemic sclerosis (SSc) seem to vary among
patients' populations recruited during different time periods. In order to verify this possible …

Vascular disease is a hallmark of systemic sclerosis (SSc). It is present in every patient,
being responsible both for the earliest clinical manifestations and the major life-threatening …

Vasculopathy has a major role in the pathogenesis and tissue injury in systemic sclerosis
(SSc). Raynaud's phenomenon (RP) is frequently the first clinical manifestation of SSc …

Fecal calprotectin (FC) is a simple, non-invasive and reproducible test, which has been
described to be highly elevated in patients with active inflammatory bowel diseases …

Background and Objective Acne is a common skin disease that often leads to scarring.
Collagen and other tissue damage from the inflammation of acne give rise to permanent skin …

Systemic sclerosis is a connective tissue disease with cutaneous involvement. Clinical
manifestations result from the balance of inflammations/autoimmunity process and …