Abstract Aims The Digitalis Investigation Group (DIG) trial, the only large randomized trial of
digoxin in heart failure, reported a neutral effect on mortality and a significant reduction in …

Aim: Recently, digoxin use has been found to associate with higher mortality. Yet, potential
mechanisms by which digoxin use increases mortality remain unclear. Increased …

Objective—Circulating levels of cardiotonic steroids (CTS) are elevated in various chronic
inflammatory conditions, but the role of CTS in inflammation remains largely unknown. We …

Background Recently published studies suggested that digoxin may increase mortality in
heart failure with reduced ejection fraction (HFrEF). However, in the vast majority of former …

(1) Introduction: Digitalis use in patients with severe heart failure is controversial. We
assessed the effects of digitalis therapy on mortality in a large, observational study in …

Aims Despite lacking supporting randomized trials, cardiac glycosides (CGs) are widely
used in heart failure and/or atrial fibrillation. Moreover, several pro-and retrospective studies …

Background: Digitalis has been widely utilized for heart failure therapy and several studies
have demonstrated an association of digitalis and adverse outcome events in patients …

Objective. The study sought to assess the prognostic value of treatment with digitalis on long-
term prognosis in patients with ventricular tachyarrhythmias and atrial fibrillation (AF) and/or …

Objective: This retrospective, case–control study was executed to assess the effects of
digoxin (DGX) use approaches [continuous use of DGX (cDGX) vs. intermittent use of DGX …

Objective: This study sought to assess the impact of treatment with digitalis on recurrences of
ventricular tachyarrhythmias in implantable cardioverter defibrillator (ICD) recipients with …