Insufficient development of new antibiotics and the rising resistance of bacteria to those that
we have are putting the world at risk of losing the most widely curative class of medicines …

Metabolism was once relegated to the supply of energy and biosynthetic precursors, but it
has now become clear that it is a specific mediator of nearly all physiological processes. In …

Drug resistant tuberculosis contributes significantly to the global burden of antimicrobial
resistance, often consuming a large proportion of the healthcare budget and associated …

Faithful translation of mRNA into the corresponding polypeptide is a complex multistep
process, requiring accurate amino acid selection, transfer RNA (tRNA) charging and mRNA …

The role of Igs in natural protection against infection by Mycobacterium tuberculosis (Mtb),
the causative agent of TB, is controversial. Although passive immunization with mAbs …

Mycobacterium tuberculosis (Mtb) exposure drives antibody responses, but whether patients
with active tuberculosis elicit protective antibodies, and against which antigens, is still …

Rifamycins are a class of antibiotics that were first discovered in 1957 and are known for
their use in treating tuberculosis (TB). Rifamycins exhibit bactericidal activity against many …

Metrics commonly used to describe antibiotic efficacy rely on measurements performed on
bacterial populations. However, certain cells in a bacterial population can continue to grow …

Two parallel revolutions were born in the golden era of antibiotics (~ 1940 to 1960). One
was a revolution in medicine as physicians went to war with microbes. The second was a …

Are antibodies important for protection against tuberculosis? The jury has been out for more
than 100 years. B cell depletion in experimental Mycobacterium tuberculosis infection failed …