The previous decade has seen a rapid increase in microglial studies on pain, with a unique
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …

Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …

Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular
nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y 1, P2Y 2, P2Y 4, P2Y …

Microglia play pivotal roles in controlling CNS functions in diverse physiological and
pathological contexts, including neuropathic pain, a chronic pain condition caused by …

There is a brief introductory summary of purinergic signaling involving ATP storage, release,
and ectoenzymatic breakdown, and the current classification of receptor subtypes for …

Intractable neuropathic pain is a frequent consequence of nerve injury or disease. When
peripheral nerves are injured, damaged axons undergo Wallerian degeneration. Schwann …

Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular
nucleotides. There are eight mammalian P2Y receptor subtypes divided into two subgroups …

The nervous system detects and interprets a variety of chemical, mechanical, and thermal
stimuli. In the face of tissue injury, local inflammatory products perpetuate ongoing activity …

Although psychotropic drugs act on neurons and glial cells, how glia respond, and whether
glial responses are involved in therapeutic effects are poorly understood. Here, we show …

Diurnal variations in pain hypersensitivity are common in chronic pain disorders, but the
underlying mechanisms are enigmatic. Here, we report that mechanical pain hypersensitivity …