Sex determination is the process deciding the sex of a developing embryo. This is usually
determined genetically; however it is a delicate process, which in many cases can be …

GATA1 is a prototypical lineage-restricted transcription factor that is central to the correct
differentiation, proliferation and apoptosis of erythroid and megakaryocytic cells. Mutations …

In response to anemia, erythropoietin (Epo) gene transcription is markedly induced in the
kidney and liver. To elucidate how Epo gene expression is regulated in vivo, we established …

Genetic modification is critically enabling for studies addressing specification and
maintenance of cell fate; however, methods for engineering modifications are inefficient. We …

GATA transcription factor family members GATA1 and GATA2 play crucial roles in the
regulation of lineage-restricted genes during erythroid differentiation. GATA1 is …

GATA factors regulate critical events in hematopoietic lineages (GATA-1/2/3), the heart and
gut (GATA-4/5/6) and various other tissues. Transgenic approaches have revealed that …

Strict regulations of the Gata1 and Gata2 genes are critical for proper lineage commitment
and development of erythroid cells. It has been shown in transgenic mouse analyses that cis …

How cell proliferation subsides as cells terminally differentiate remains largely enigmatic,
although this phenomenon is central to the existence of multicellular organisms. Here, we …

GATA-1 is essential for the development of erythroid and megakaryocytic lineages. We
found that GATA-1 gene knockdown female (GATA-1.05/X) mice frequently develop a …

The transcription factors GATA1 and GATA2 are fundamental regulators of hematopoiesis
and have overlapping expression profiles. GATA2 is expressed in hematopoietic stem cells …