Role of goblet cells in intestinal barrier and mucosal immunity

S Yang, M Yu - Journal of inflammation research, 2021 - Taylor & Francis
Goblet cells and the mucus they secrete serve as an important barrier, preventing pathogens
from invading the mucosa to cause intestinal inflammation. The perspective regarding goblet …

Fight them or feed them: how the intestinal mucus layer manages the gut microbiota

BO Schroeder - Gastroenterology report, 2019 - academic.oup.com
The intestinal tract is inhabited by a tremendous number of microorganisms, termed the gut
microbiota. These microorganisms live in a mutualistic relationship with their host and assist …

[HTML][HTML] Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis

J Fang, H Wang, Y Zhou, H Zhang, H Zhou… - … & molecular medicine, 2021 - nature.com
Ulcerative colitis (UC) is a chronic recurrent intestinal inflammatory disease characterized by
high incidence and young onset age. Recently, there have been some interesting findings in …

[HTML][HTML] Goblet cells: multifaceted players in immunity at mucosal surfaces

KA Knoop, RD Newberry - Mucosal immunology, 2018 - Elsevier
Goblet cells (GCs) are specialized epithelial cells that line multiple mucosal surfaces and
have a well-appreciated role in barrier maintenance through the secretion of mucus …

Bifidobacterium dentium fortifies the intestinal mucus layer via autophagy and calcium signaling pathways

MA Engevik, B Luk, AL Chang-Graham, A Hall… - MBio, 2019 - Am Soc Microbiol
Much remains unknown about how the intestinal microbiome interfaces with the protective
intestinal mucus layer. Bifidobacterium species colonize the intestinal mucus layer and can …

Experimental models to study intestinal microbes–mucus interactions in health and disease

L Etienne-Mesmin, B Chassaing… - FEMS microbiology …, 2019 - academic.oup.com
ABSTRACT A close symbiotic relationship exists between the intestinal microbiota and its
host. A critical component of gut homeostasis is the presence of a mucus layer covering the …

[HTML][HTML] Akkermansia muciniphila Protects Against Psychological Disorder-Induced Gut Microbiota-Mediated Colonic Mucosal Barrier Damage and Aggravation of …

T Chen, R Wang, Z Duan, X Yuan, Y Ding… - Frontiers in Cellular …, 2021 - frontiersin.org
Psychological disorders are associated with increased risk of severe inflammatory bowel
disease (IBD) by causing gut microbiota dysbiosis and colonic mucosal barrier damage …

[HTML][HTML] The Dynamic Changes of Gut Microbiota in Muc2 Deficient Mice

M Wu, Y Wu, J Li, Y Bao, Y Guo, W Yang - International journal of …, 2018 - mdpi.com
Gut dysbiosis is associated with colitis-associated colorectal carcinogenesis, and the
genetic deficiency of the Muc2 gene causes spontaneous development of colitis and …

Effects of Flammulina velutipes polysaccharide on immune response and intestinal microbiota in mice

R Zhao, Q Hu, G Ma, A Su, M Xie, X Li, G Chen… - Journal of Functional …, 2019 - Elsevier
A crude polysaccharide derived from Flammulina velutipes (FVP), mainly consisting of
glucose linked with β-glycosidic bonds, was administered to 6 week-old male ICR mice by …

[HTML][HTML] Gut microbial metabolite-mediated regulation of the intestinal barrier in the pathogenesis of inflammatory bowel disease

N Iyer, SC Corr - Nutrients, 2021 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic inflammatory disease. The disease has a
multifactorial aetiology, involving genetic, microbial as well as environmental factors. The …