Antiviral activities of human host defense peptides
Peptides with broad-spectrum antimicrobial activity are found widely expressed throughout
nature. As they participate in a number of different aspects of innate immunity in mammals …
nature. As they participate in a number of different aspects of innate immunity in mammals …
Evolution and diversity of immune responses during acute HIV infection
Understanding the earliest immune responses following HIV infection is critical to inform
future vaccines and therapeutics. Here, we review recent prospective human studies in at …
future vaccines and therapeutics. Here, we review recent prospective human studies in at …
Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection
Cellular immunity is critical for controlling intracellular pathogens, but individual cellular
dynamics and cell–cell cooperativity in evolving human immune responses remain poorly …
dynamics and cell–cell cooperativity in evolving human immune responses remain poorly …
Smoking and Human Immunodeficiency Virus 1 Infection Promote Retention of CD8+ T Cells in the Airway Mucosa
Smoking and human immunodeficiency virus 1 (HIV-1) infection are risk factors for chronic
obstructive pulmonary disease (COPD), which is among the most common comorbid …
obstructive pulmonary disease (COPD), which is among the most common comorbid …
[HTML][HTML] Microbial mismanagement: how inadequate treatments for vaginal dysbiosis drive the HIV epidemic in women
A Gustin, R Cromarty, L Schifanella, NR Klatt - Seminars in immunology, 2021 - Elsevier
Women and girls represent a key population driving new HIV infections and persistence of
the HIV pandemic. A key determinant of HIV susceptibility is the composition of the vaginal …
the HIV pandemic. A key determinant of HIV susceptibility is the composition of the vaginal …
[HTML][HTML] Interferons at the crossroad of cell death pathways during gastrointestinal inflammation and infection
I Stolzer, B Ruder, MF Neurath, C Günther - International Journal of …, 2021 - Elsevier
Interferons (IFNs) are pleiotropic immune-modulatory cytokines that are well known for their
essential role in host defense against viruses, bacteria, and other pathogenic …
essential role in host defense against viruses, bacteria, and other pathogenic …
Modulation of human β-defensin-1 production by viruses
While initially identified as a broad-spectrum antimicrobial peptide, constitutively expressed
in epithelia, human β-defensin (hBD)-1 is now recognized to have a more complex pattern of …
in epithelia, human β-defensin (hBD)-1 is now recognized to have a more complex pattern of …
Integrated transcriptomic and proteomic analysis of red blood cells from rainbow trout challenged with VHSV point towards novel immunomodulant targets
I Nombela, M Lopez-Lorigados, ME Salvador-Mira… - Vaccines, 2019 - mdpi.com
Teleost red blood cells (RBCs) are nucleated and therefore can propagate cellular
responses to exogenous stimuli. RBCs can mount an immune response against a variety of …
responses to exogenous stimuli. RBCs can mount an immune response against a variety of …
[HTML][HTML] 宿主防御肽抗病毒感染机制研究进展
万超， 彭练慈， 叶超 - 微生物学报, 2023 - actamicro.ijournals.cn
宿主防御肽是一类广泛存在于脊椎动物的小分子多肽, 具有广谱的抗菌活性以及抗炎, 细胞趋化,
促进血管生成和修复损伤等免疫调节功能. 以往的研究多集中在宿主防御肽抗细菌和真菌感染的 …
促进血管生成和修复损伤等免疫调节功能. 以往的研究多集中在宿主防御肽抗细菌和真菌感染的 …
Identification of novel disease-relevant genes and pathways in the pathogenesis of type 1 diabetes: a potential defect in pancreatic iron homeostasis
L Yip, R Alkhataybeh, C Taylor, R Fuhlbrigge… - Diabetes, 2022 - Am Diabetes Assoc
Multiple pathways contribute to the pathophysiological development of type 1 diabetes
(T1D); however, the exact mechanisms involved are unclear. We performed differential gene …
(T1D); however, the exact mechanisms involved are unclear. We performed differential gene …