Research conducted during the past 30 years has increased our understanding of the
mechanisms involved in colorectal cancer initiation and development. The findings have …

Molecular classification of colorectal cancer is evolving. As our understanding of colorectal
carcinogenesis improves, we are incorporating new knowledge into the classification …

A deficient mismatch repair system (dMMR) is present in 10–20% of patients with sporadic
colorectal cancer (CRC) and is associated with a favourable prognosis in early stage …

The NCCN Clinical Practice Guidelines in Oncology for Colon Cancer begin with the clinical
presentation of the patient to the primary care physician or gastroenterologist and address …

Background Aerobic glycolysis, namely the Warburg effect, is the main hallmark of cancer
cells. Mitochondrial respiratory dysfunction has been proposed to be one of the major …

Background & Aims: 5-Fluorouracil (FU) is one of the mainstays of colon cancer
chemotherapy. Although developed as an inhibitor of thymidylate synthase, its cytotoxicity …

The CpG island methylator phenotype (CIMP) is a distinct epigenetic phenotype in colorectal
carcinoma with concordant methylation in multiple promoter CpG islands. The relationship …

Colorectal cancer (CRC) represents the third most common type of cancer in developed
countries and one of the leading causes of cancer deaths worldwide. Personalized …

Colorectal carcinoma (CRC) is characterized by wide intratumor heterogeneity with general
genomic instability and there is a need for improved diagnostic, prognostic, and therapeutic …

Background DNA deficient mismatch repair (dMMR) genes are associated with
microsatellite instability and good prognosis in early-stage colorectal cancer (CRC) …