[HTML][HTML] Fetal and neonatal alloimmune thrombocytopenia: Current pathophysiological insights and perspectives for future diagnostics and treatment
W Stam, GE Wachholz, JM de Pereda, R Kapur… - Blood reviews, 2023 - Elsevier
FNAIT is a pregnancy-associated condition caused by maternal alloantibodies against
paternally-inherited platelet antigens, most frequently HPA-1a on integrin β3. The clinical …
paternally-inherited platelet antigens, most frequently HPA-1a on integrin β3. The clinical …
[HTML][HTML] Progress and development of platelet antibody detection
L Porcelijn, E Huiskes, M de Haas - Transfusion and Apheresis Science, 2020 - Elsevier
Human platelet antibody (HPA) detection is necessary for the diagnosis and therapeutic
decisions for refractoriness to platelet transfusions, post transfusion purpura and fetal and …
decisions for refractoriness to platelet transfusions, post transfusion purpura and fetal and …
An integrin αIIbβ3 intermediate affinity state mediates biomechanical platelet aggregation
Integrins are membrane receptors that mediate cell adhesion and mechanosensing. The
structure–function relationship of integrins remains incompletely understood, despite the …
structure–function relationship of integrins remains incompletely understood, despite the …
Dynamic bonds and their roles in mechanosensing
Mechanical forces are ubiquitous in a cell's internal structure and external environment.
Mechanosensing is the process that the cell employs to sense its mechanical environment …
Mechanosensing is the process that the cell employs to sense its mechanical environment …
Prophylactic administration of HPA-1a–specific antibodies prevents fetal/neonatal alloimmune thrombocytopenia in mice
Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a life-threatening bleeding disorder
caused by maternal alloantibodies directed against paternally inherited human platelet …
caused by maternal alloantibodies directed against paternally inherited human platelet …
Thy-1 (CD90)-regulated cell adhesion and migration of mesenchymal cells: insights into adhesomes, mechanical forces, and signaling pathways
Cell adhesion and migration depend on the assembly and disassembly of adhesive
structures known as focal adhesions. Cells adhere to the extracellular matrix (ECM) and …
structures known as focal adhesions. Cells adhere to the extracellular matrix (ECM) and …
[HTML][HTML] Tenascin-C restricts reactive astrogliosis in the ischemic brain
E Dzyubenko, D Manrique-Castano, M Pillath-Eilers… - Matrix Biology, 2022 - Elsevier
Cellular responses in glia play a key role in regulating brain remodeling post-stroke.
However, excessive glial reactivity impedes post-ischemic neuroplasticity and hampers …
However, excessive glial reactivity impedes post-ischemic neuroplasticity and hampers …
High-resolution mapping of the polyclonal immune response to the human platelet alloantigen HPA-1a (PlA1)
Antibodies to platelet-specific antigens are responsible for 2 clinically important bleeding
disorders: posttransfusion purpura and fetal/neonatal alloimmune thrombocytopenia …
disorders: posttransfusion purpura and fetal/neonatal alloimmune thrombocytopenia …
[HTML][HTML] Family-wide analysis of integrin structures predicted by AlphaFold2
H Zhang, DS Zhu, J Zhu - Computational and Structural Biotechnology …, 2023 - Elsevier
Recent advances in protein structure prediction using AlphaFold2, known for its high
efficiency and accuracy, have opened new avenues for comprehensive analysis of all …
efficiency and accuracy, have opened new avenues for comprehensive analysis of all …
Full-length αIIbβ3 cryo-EM structure reveals intact integrin initiate-activation intrinsic architecture
Integrin αIIbβ3 is the key receptor regulating platelet retraction and accumulation and a
proven drug-target for antithrombotic therapies. Here we resolve the cryo-EM structures of …
proven drug-target for antithrombotic therapies. Here we resolve the cryo-EM structures of …