The power of any genetic model organism is derived, in part, from the ease with which gene
expression can be manipulated. The short generation time and invariant developmental …

The enormous diversity of cell types that characterizes any animal nervous system is defined
by neuron-type-specific gene batteries that endow cells with distinct anatomical and …

We have produced gene expression profiles of all 302 neurons of the C. elegans nervous
system that match the single-cell resolution of its anatomy and wiring diagram. Our results …

Highlights•Terminal selector control terminal steps of neuronal identity acquisition.•Terminal
selectors establish and maintain neuron type-specific identity features.•Terminal selectors …

Jellyfish (medusae) are a distinctive life-cycle stage of medusozoan cnidarians. They are
major marine predators, with integrated neurosensory, muscular and organ systems. The …

Complex biological processes such as embryogenesis require precise coordination of cell
differentiation programs across both space and time. Using protein-fusion fluorescent …

The dynamics of living organisms are organized across many spatial scales. However,
current cost-effective imaging systems can measure only a subset of these scales at once …

The conserved p38 MAPK family is activated by phosphorylation during stress responses
and inactivated by phosphatases. C. elegans PMK-1 p38 MAPK initiates innate immune …

The auxin-inducible degradation system in C. elegans allows for spatial and temporal
control of protein degradation via heterologous expression of a single Arabidopsis thaliana …

The continuing fascination with serotonin (5‐hydroxytryptamine, 5‐HT) as a nervous system
chemical messenger began with its discovery in the brains of mammals in 1953. Among the …