Bile acids are synthesized from cholesterol in the liver and released into the intestine to aid
the digestion of dietary lipids. The host enzymes that contribute to bile acid synthesis in the …

The liver is the central metabolic hub which coordinates nutritional inputs and metabolic
outputs. Food intake releases bile acids which can be sensed by the bile acid receptor FXR …

The side effects of cisplatin, a widely used chemotherapeutic agent, include nephrotoxicity.
Previous studies have reported that cisplatin induces ferroptosis and lipid peroxide …

FXR agonists are used to treat non-alcoholic fatty liver disease (NAFLD), in part because
they reduce hepatic lipids. Here, we show that FXR activation with the FXR agonist …

Bile acids are synthesized from cholesterol in the liver and subjected to multiple metabolic
biotransformations in hepatocytes, including oxidation by cytochromes P450 (CYPs) and …

Abstract Cholesterol 7 alpha-hydroxylase (CYP7A1, EC1. 14) is the first and rate-limiting
enzyme in the classic bile acid synthesis pathway. Much progress has been made in …

Bile acids (BAs) play a crucial role in nutrient absorption and act as key regulators of lipid
and glucose metabolism and immune homeostasis. Through the enterohepatic circulation …

The small Maf proteins (sMafs) are basic region leucine zipper (bZIP)-type transcription
factors. The basic region of the Maf family is unique among the bZIP factors, and it …

Mammals undergo regular cycles of fasting and feeding that engage dynamic transcriptional
responses in metabolic tissues. Here we review advances in our understanding of the gene …

For many years, bile acids were thought to only function as detergents which solubilize fats
and facilitate the uptake of fat-soluble vitamins in the intestine. Many early observations; …