Interactions between gut bacteria and bile in health and disease
Bile acids are synthesized from cholesterol in the liver and released into the intestine to aid
the digestion of dietary lipids. The host enzymes that contribute to bile acid synthesis in the …
the digestion of dietary lipids. The host enzymes that contribute to bile acid synthesis in the …
[HTML][HTML] FXR in liver physiology: Multiple faces to regulate liver metabolism
K Panzitt, M Wagner - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2021 - Elsevier
The liver is the central metabolic hub which coordinates nutritional inputs and metabolic
outputs. Food intake releases bile acids which can be sensed by the bile acid receptor FXR …
outputs. Food intake releases bile acids which can be sensed by the bile acid receptor FXR …
[HTML][HTML] Farnesoid X receptor protects against cisplatin-induced acute kidney injury by regulating the transcription of ferroptosis-related genes
The side effects of cisplatin, a widely used chemotherapeutic agent, include nephrotoxicity.
Previous studies have reported that cisplatin induces ferroptosis and lipid peroxide …
Previous studies have reported that cisplatin induces ferroptosis and lipid peroxide …
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption
FXR agonists are used to treat non-alcoholic fatty liver disease (NAFLD), in part because
they reduce hepatic lipids. Here, we show that FXR activation with the FXR agonist …
they reduce hepatic lipids. Here, we show that FXR activation with the FXR agonist …
Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans [S]
S Takahashi, T Fukami, Y Masuo, CN Brocker… - Journal of lipid …, 2016 - ASBMB
Bile acids are synthesized from cholesterol in the liver and subjected to multiple metabolic
biotransformations in hepatocytes, including oxidation by cytochromes P450 (CYPs) and …
biotransformations in hepatocytes, including oxidation by cytochromes P450 (CYPs) and …
[HTML][HTML] Up to date on cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis
JYL Chiang, JM Ferrell - Liver research, 2020 - Elsevier
Abstract Cholesterol 7 alpha-hydroxylase (CYP7A1, EC1. 14) is the first and rate-limiting
enzyme in the classic bile acid synthesis pathway. Much progress has been made in …
enzyme in the classic bile acid synthesis pathway. Much progress has been made in …
Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis
W Jia, Y Li, KCP Cheung, X Zheng - Science China Life Sciences, 2024 - Springer
Bile acids (BAs) play a crucial role in nutrient absorption and act as key regulators of lipid
and glucose metabolism and immune homeostasis. Through the enterohepatic circulation …
and glucose metabolism and immune homeostasis. Through the enterohepatic circulation …
Small Maf proteins (MafF, MafG, MafK): history, structure and function
F Katsuoka, M Yamamoto - Gene, 2016 - Elsevier
The small Maf proteins (sMafs) are basic region leucine zipper (bZIP)-type transcription
factors. The basic region of the Maf family is unique among the bZIP factors, and it …
factors. The basic region of the Maf family is unique among the bZIP factors, and it …
Hepatic transcriptional responses to fasting and feeding
L Bideyan, R Nagari, P Tontonoz - Genes & development, 2021 - genesdev.cshlp.org
Mammals undergo regular cycles of fasting and feeding that engage dynamic transcriptional
responses in metabolic tissues. Here we review advances in our understanding of the gene …
responses in metabolic tissues. Here we review advances in our understanding of the gene …
Pharmacology of bile acid receptors: Evolution of bile acids from simple detergents to complex signaling molecules
BL Copple, T Li - Pharmacological research, 2016 - Elsevier
For many years, bile acids were thought to only function as detergents which solubilize fats
and facilitate the uptake of fat-soluble vitamins in the intestine. Many early observations; …
and facilitate the uptake of fat-soluble vitamins in the intestine. Many early observations; …