Recent work has revealed that the neural activity patterns correlated with sensation,
cognition, and action often are not stable and instead undergo large scale changes over …

Tremendous strides have been made in our understanding of the neurobiological substrates
of memory–the so-called memory “engram”. Here, we integrate recent progress in the …

While memories are often thought of as flashbacks to a previous experience, they do not
simply conserve veridical representations of the past but must continually integrate new …

The ability to store and retrieve learned information over prolonged periods of time is an
essential and intriguing property of the brain. Insight into the neurobiological mechanisms …

Highlights•Endogenous fluctuations in cellular excitability support time-stamping and
memory-updating across time and experience.•Molecularly distinct subensembles may …

Memories are encoded by sparse populations of neurons but how such sparsity arises
remains largely unknown. We found that a neuron's eligibility to be recruited into the memory …

Hippocampal CA1 parvalbumin-expressing interneurons (PV INs) play a central role in
controlling principal cell activity and orchestrating network oscillations. PV INs receive …

Episodic events are frequently consolidated into labile memory but are not necessarily
transferred to persistent long-term memory (LTM). Regulatory mechanisms leading to LTM …

Ghrelin is a circulating peptide hormone that promotes feeding and regulates metabolism in
humans and rodents. The action of ghrelin is mediated by the growth hormone …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by memory
loss and progressive cognitive impairments. In mouse models of AD pathology, studies have …