[HTML][HTML] Representational drift: Emerging theories for continual learning and experimental future directions
Recent work has revealed that the neural activity patterns correlated with sensation,
cognition, and action often are not stable and instead undergo large scale changes over …
cognition, and action often are not stable and instead undergo large scale changes over …
[HTML][HTML] Engram neurons: Encoding, consolidation, retrieval, and forgetting of memory
A Guskjolen, MS Cembrowski - Molecular psychiatry, 2023 - nature.com
Tremendous strides have been made in our understanding of the neurobiological substrates
of memory–the so-called memory “engram”. Here, we integrate recent progress in the …
of memory–the so-called memory “engram”. Here, we integrate recent progress in the …
[HTML][HTML] The brain in motion: How ensemble fluidity drives memory-updating and flexibility
W Mau, ME Hasselmo, DJ Cai - Elife, 2020 - elifesciences.org
While memories are often thought of as flashbacks to a previous experience, they do not
simply conserve veridical representations of the past but must continually integrate new …
simply conserve veridical representations of the past but must continually integrate new …
[HTML][HTML] A synaptic framework for the persistence of memory engrams
P Rao-Ruiz, E Visser, M Mitrić, AB Smit… - Frontiers in synaptic …, 2021 - frontiersin.org
The ability to store and retrieve learned information over prolonged periods of time is an
essential and intriguing property of the brain. Insight into the neurobiological mechanisms …
essential and intriguing property of the brain. Insight into the neurobiological mechanisms …
Dynamic and heterogeneous neural ensembles contribute to a memory engram
Highlights•Endogenous fluctuations in cellular excitability support time-stamping and
memory-updating across time and experience.•Molecularly distinct subensembles may …
memory-updating across time and experience.•Molecularly distinct subensembles may …
Chromatin plasticity predetermines neuronal eligibility for memory trace formation
Memories are encoded by sparse populations of neurons but how such sparsity arises
remains largely unknown. We found that a neuron's eligibility to be recruited into the memory …
remains largely unknown. We found that a neuron's eligibility to be recruited into the memory …
[HTML][HTML] mTORC1 function in hippocampal parvalbumin interneurons: regulation of firing and long-term potentiation of intrinsic excitability but not long-term contextual …
Hippocampal CA1 parvalbumin-expressing interneurons (PV INs) play a central role in
controlling principal cell activity and orchestrating network oscillations. PV INs receive …
controlling principal cell activity and orchestrating network oscillations. PV INs receive …
CREBA and CREBB in two identified neurons gate long-term memory formation in Drosophila
HW Lin, CC Chen, JS de Belle… - Proceedings of the …, 2021 - National Acad Sciences
Episodic events are frequently consolidated into labile memory but are not necessarily
transferred to persistent long-term memory (LTM). Regulatory mechanisms leading to LTM …
transferred to persistent long-term memory (LTM). Regulatory mechanisms leading to LTM …
Ghrelin signaling in dCA1 suppresses neuronal excitability and impairs memory acquisition via PI3K/Akt/GSK-3β cascades
Ghrelin is a circulating peptide hormone that promotes feeding and regulates metabolism in
humans and rodents. The action of ghrelin is mediated by the growth hormone …
humans and rodents. The action of ghrelin is mediated by the growth hormone …
Progressive excitability changes in the medial entorhinal cortex in the 3xTg mouse model of Alzheimer's disease pathology
Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by memory
loss and progressive cognitive impairments. In mouse models of AD pathology, studies have …
loss and progressive cognitive impairments. In mouse models of AD pathology, studies have …