Abstract Formulation development for preclinical studies is an essential part of the drug
discovery and development process in that it enables pharmacokinetics, efficacy, and safety …

The incidence of the structural features on the self-assembly of different poloxamines (the
conventional sequential Tetronic 304, 901, 904, 908, 1107, 1301, and 1307; a reverse …

Forced degradation study is the degradation of new drug substances and drug products in
more severe conditions than accelerated conditions. Forced degradation study were …

Objectives: This study focuses on the development of a dry powder inhaler (DPI) formulation
of simvastatin (SV), and the effects of SV on the respiratory epithelium. Methods: Micronised …

The present study aimed to optimize a liposomal formulation co-encapsulating simvastatin
(SIM) and doxorubicin (DOX) that has future perspectives in anticancer therapy. The …

The present study evaluates a new method to prepare nanoparticles of a poorly water-
soluble drug, simvastatin, by evaporation of all solvents from spontaneously formed oil-in …

Herein, a microextraction method was reported based on the liquid-solid phase transition of
benzoic acid to quantify two statins, namely lovastatin and simvastatin in authentic human …

Introduction: Although pharmacogenetics and pharmacogenomics have been at the forefront
of research aimed at finding novel personalized therapies, the focus of research has recently …

Local delivery of active agents using injectable or implantable hydrogels for tissue and bone
regeneration is a promising therapy, but it remains challenging for controlling dose and …

A simple, specific and sensitive reverse phase high performance liquid chromatographic
method was developed and validated for simultaneous determination of ezetimibe and …