[HTML][HTML] Glycomimetics for the inhibition and modulation of lectins
Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …
Glycomimetics versus multivalent glycoconjugates for the design of high affinity lectin ligands
One could certainly highlight a conceptual resemblance between social interactions as the
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …
[HTML][HTML] From carbohydrate leads to glycomimetic drugs
B Ernst, JL Magnani - Nature reviews Drug discovery, 2009 - nature.com
Carbohydrates are the most abundant natural products. Besides their role in metabolism
and as structural building blocks, they are fundamental constituents of every cell surface …
and as structural building blocks, they are fundamental constituents of every cell surface …
[HTML][HTML] FimH and anti-adhesive therapeutics: a disarming strategy against uropathogens
Chaperone-usher fimbrial adhesins are powerful weapons against the uropathogens that
allow the establishment of urinary tract infections (UTIs). As the antibiotic therapeutic …
allow the establishment of urinary tract infections (UTIs). As the antibiotic therapeutic …
The biology and future prospects of antivirulence therapies
L Cegelski, GR Marshall, GR Eldridge… - Nature Reviews …, 2008 - nature.com
The emergence and increasing prevalence of bacterial strains that are resistant to available
antibiotics demand the discovery of new therapeutic approaches. Targeting bacterial …
antibiotics demand the discovery of new therapeutic approaches. Targeting bacterial …
Anti-virulence strategies to target bacterial infections
S Mühlen, P Dersch - How to Overcome the Antibiotic Crisis: Facts …, 2016 - Springer
Resistance of important bacterial pathogens to common antimicrobial therapies and the
emergence of multidrug-resistant bacteria are increasing at an alarming rate and constitute …
emergence of multidrug-resistant bacteria are increasing at an alarming rate and constitute …
[HTML][HTML] Protein nanowires with tunable functionality and programmable self-assembly using sequence-controlled synthesis
DM Shapiro, G Mandava, SE Yalcin… - Nature …, 2022 - nature.com
Advances in synthetic biology permit the genetic encoding of synthetic chemistries at
monomeric precision, enabling the synthesis of programmable proteins with tunable …
monomeric precision, enabling the synthesis of programmable proteins with tunable …
Effects of yeast culture supplementation on growth performance, intestinal health, and immune response of nursery pigs
ABSTRACT A total of 216 weaning pigs were used in 2 experiments to determine the effects
of dietary supplementation of yeast culture (YC) at different dose levels on the growth …
of dietary supplementation of yeast culture (YC) at different dose levels on the growth …
Carbohydrates as future anti-adhesion drugs for infectious diseases
N Sharon - Biochimica et Biophysica Acta (BBA)-General Subjects, 2006 - Elsevier
Adhesion of pathogenic organisms to host tissues is the prerequisite for the initiation of the
majority of infectious diseases. In many systems, it is mediated by lectins present on the …
majority of infectious diseases. In many systems, it is mediated by lectins present on the …
Treatment and prevention of urinary tract infection with orally active FimH inhibitors
CK Cusumano, JS Pinkner, Z Han, SE Greene… - Science translational …, 2011 - science.org
Chronic and recurrent urinary tract infections pose a serious medical problem because there
are few effective treatment options. Patients with chronic urinary tract infections are …
are few effective treatment options. Patients with chronic urinary tract infections are …