Cerebral small vessel disease (SVD) causes lacunar stroke and intracerebral hemorrhage,
and is the most common pathology underlying vascular cognitive impairment. Increasingly …

Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Small vessel disease is a disorder of cerebral microvessels that causes white matter
hyperintensities and several other common abnormalities (eg, recent small subcortical …

The optimal management of post-stroke cognitive impairment remains controversial. These
joint European Stroke Organisation (ESO) and European Academy of Neurology (EAN) …

Hypertension is the most important modifiable cause of cardiovascular (CV) disease and all-
cause mortality worldwide. Despite the positive correlations between blood pressure (BP) …

'Covert'cerebral small vessel disease (ccSVD) is common on neuroimaging in persons
without overt neurological manifestations, and increases the risk of future stroke, cognitive …

Despite advances in acute management and prevention of cerebrovascular disease, stroke
and vascular cognitive impairment together remain the world's leading cause of death and …

Hypertension-associated cerebral small vessel disease is a common finding in older people.
Strongly associated with age and hypertension, small vessel disease is found at autopsy in …

Importance Cerebral small vessel disease (SVD) causes a quarter of strokes and is the most
common pathology underlying vascular cognitive impairment and dementia. An important …

Objectives To determine if lower blood pressure targets (systolic/diastolic 135/85 mmHg or
less) are associated with reduction in mortality and morbidity compared with standard blood …