Cerebral palsy: an overview

K Vitrikas, H Dalton, D Breish - American family physician, 2020 - aafp.org
Cerebral palsy is defined as a group of disorders that affects an individual's movement,
posture, and balance due to injury to the developing brain. Treatments for the movement …

Botulinum toxin A injection in treatment of upper limb spasticity in children with cerebral palsy: a systematic review of randomized controlled trials

SM Farag, MO Mohammed, TA El-Sobky… - JBJS …, 2020 - journals.lww.com
Background: Cerebral palsy (CP) is the most common cause of childhood disability globally.
Botulinum toxin A injections are widely used to manage limb spasticity in children with CP …

[PDF][PDF] Single residue variation in skeletal muscle myosin enables direct and selective drug targeting for spasticity and muscle stiffness

M Gyimesi, ÁI Horváth, D Túrós, SK Suthar, M Pénzes… - Cell, 2020 - cell.com
Muscle spasticity after nervous system injuries and painful low back spasm affect more than
10% of global population. Current medications are of limited efficacy and cause neurological …

Loss of myogenic potential and fusion capacity of muscle stem cells isolated from contractured muscle in children with cerebral palsy

AA Domenighetti, MA Mathewson… - … of Physiology-Cell …, 2018 - journals.physiology.org
Cerebral palsy (CP) is the most common cause of pediatric neurodevelopmental and
physical disability in the United States. It is defined as a group of motor disorders caused by …

[HTML][HTML] Recent developments in muscle synergy analysis in young people with neurodevelopmental diseases: A Systematic Review

G Beltrame, A Scano, G Marino, A Peccati… - … in Bioengineering and …, 2023 - frontiersin.org
The central nervous system simplifies motor control by sending motor commands activating
groups of muscles, known as synergies. Physiological locomotion can be described as a …

Botulinum Toxin—A High-Dosage Effect on Functional Outcome and Spasticity-Related Pain in Subjects with Stroke

D Intiso, AM Centra, M Gravina, A Chiaramonte… - Toxins, 2023 - mdpi.com
Stroke patients can develop spasticity and spasticity-related pain (SRP). These disorders
are frequent and can contribute to functional limitations and disabling conditions. Many …

IncobotulinumtoxinA for the treatment of lower-limb spasticity in children and adolescents with cerebral palsy: A phase 3 study

F Heinen, P Kanovský, AS Schroeder… - Journal of pediatric …, 2021 - content.iospress.com
PURPOSE: Investigate the efficacy and safety of multipattern incobotulinumtoxinA injections
in children/adolescents with lower-limb cerebral palsy (CP)-related spasticity. METHODS …

Intramuscular botulinum toxin prior to comprehensive rehabilitation has no added value for improving motor impairments, gait kinematics and goal attainment in …

F Schasfoort, R Pangalila, E Sneekes… - Journal of …, 2018 - repub.eur.nl
Objective: Botulinum toxin (BoNT-A) is widely used in combined treatment for spastic
cerebral palsy, but its added value preceding comprehensive rehabilitation for motor …

Localization of the center of the intramuscular nerve dense region of the medial femoral muscles and the significance for blocking spasticity

J Wang, Q Wang, D Zhu, Y Jiang, S Yang - Annals of Anatomy …, 2020 - Elsevier
Purpose To identify the body surface position and depth of the center of the intramuscular
nerves dense region (CINDR) of the medial femoral muscles. Methods Utilizing twelve …

Iatrogenic botulism outbreak in egypt due to a counterfeit botulinum toxin a preparation–A descriptive series of patient features and outcome

EAMA Rashid, NM ElMahdy… - Basic & Clinical …, 2018 - Wiley Online Library
Iatrogenic botulism resulting from the substantial increase in use of botulinum neurotoxin
type A (Bo NTA) treatment is rarely reported. We aimed to describe a large iatrogenic …