IRES trans-acting factors, key actors of the stress response

AC Godet, F David, F Hantelys, F Tatin… - International journal of …, 2019 - mdpi.com
The cellular stress response corresponds to the molecular changes that a cell undergoes in
response to various environmental stimuli. It induces drastic changes in the regulation of …

[HTML][HTML] Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity

J Massart, K Begriche, C Moreau… - Journal of clinical and …, 2017 - ncbi.nlm.nih.gov
Background: Obesity is often associated with nonalcoholic fatty liver disease (NAFLD),
which refers to a large spectrum of hepatic lesions including fatty liver, nonalcoholic …

Quercetin reduces lipid accumulation in a cell model of NAFLD by inhibiting de novo fatty acid synthesis through the acetyl-CoA carboxylase 1/AMPK/PP2A axis

A Gnoni, B Di Chiara Stanca, L Giannotti… - International Journal of …, 2022 - mdpi.com
Dysregulation of de novo lipogenesis (DNL) has recently gained strong attention as being
one of the critical factors that contribute to the assessment of non-alcoholic fatty liver disease …

A comprehensive understanding of hnRNP A1 role in cancer: new perspectives on binding with noncoding RNA

L Siculella, L Giannotti, B Di Chiara Stanca… - Cancer gene …, 2023 - nature.com
The heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is the most abundant and
ubiquitously expressed member of the heterogeneous nuclear ribonucleoproteins family …

Long noncoding RNA lncSHGL recruits hnRNPA1 to suppress hepatic gluconeogenesis and lipogenesis

J Wang, W Yang, Z Chen, J Chen, Y Meng, B Feng… - Diabetes, 2018 - Am Diabetes Assoc
Mammalian genomes encode a huge number of long noncoding RNAs (lncRNAs) with
unknown functions. This study determined the role and mechanism of a new lncRNA …

Protective effect of quercetin against the metabolic dysfunction of glucose and lipids and its associated learning and memory impairments in NAFLD rats

XR Gao, Z Chen, K Fang, JX Xu, JF Ge - Lipids in health and disease, 2021 - Springer
Background Quercetin (QUE) is a flavonol reported with anti-inflammatory and antioxidant
activities, and previous results from the group of this study have demonstrated its …

Mitochondrial fusion regulates lipid homeostasis and stem cell maintenance in the Drosophila testis

R Sênos Demarco, BS Uyemura, C D'Alterio… - Nature cell …, 2019 - nature.com
The capacity of stem cells to self-renew or differentiate has been attributed to distinct
metabolic states. A genetic screen targeting regulators of mitochondrial dynamics revealed …

The role of CSDE1 in translational reprogramming and human diseases

AX Guo, JJ Cui, LY Wang, JY Yin - Cell Communication and Signaling, 2020 - Springer
CSDE1 (cold shock domain containing E1) plays a key role in translational reprogramming,
which determines the fate of a number of RNAs during biological processes. Interestingly …

Mitophagy in hepatic insulin resistance: therapeutic potential and concerns

Z Su, Y Nie, X Huang, Y Zhu, B Feng, L Tang… - Frontiers in …, 2019 - frontiersin.org
Metabolic syndrome, characterized by central obesity, hypertension, and hyperlipidemia,
increases the morbidity and mortality of cardiovascular disease, type 2 diabetes …

Post-translational modifications of hnRNP A1 differentially modulate retroviral IRES-mediated translation initiation

A Barrera, H Ramos, J Vera-Otarola… - Nucleic Acids …, 2020 - academic.oup.com
The full-length mRNAs of the human immunodeficiency virus type-1 (HIV-1), the human T-
cell lymphotropic virus type-1 (HTLV-1), and the mouse mammary tumor virus (MMTV) …