Macrovascular complications of type 2 diabetes mellitus

M Viigimaa, A Sachinidis… - Current vascular …, 2020 - ingentaconnect.com
Background: Type 2 diabetes mellitus (T2DM) has emerged as a pandemic. It has different
complications, both microvascular and macrovascular. Objective: The purpose of this review …

Macrovascular complications in patients with diabetes and prediabetes

D Huang, M Refaat, K Mohammedi… - BioMed research …, 2017 - Wiley Online Library
Diabetes is a significant health problem worldwide, and its association with cardiovascular
disease (CVD) was reported in several studies. Hyperglycemia and insulin resistance seen …

Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I

F Paneni, JA Beckman, MA Creager… - European heart …, 2013 - academic.oup.com
Hyperglycemia and insulin resistance are key players in the development of atherosclerosis
and its complications. A large body of evidence suggest that metabolic abnormalities cause …

Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation

P Dandona, A Aljada, A Chaudhuri, P Mohanty… - Circulation, 2005 - Am Heart Assoc
insulin because of insulin resistance would thus result in the activation of these
proinflammatory transcription factors and an increase in the expression of the corresponding …

Hyperglycemia–related mortality in critically ill patients varies with admission diagnosis

M Falciglia, RW Freyberg, PL Almenoff… - Critical care …, 2009 - journals.lww.com
Objectives: Hyperglycemia during critical illness is common and is associated with
increased mortality. Intensive insulin therapy has improved outcomes in some, but not all …

NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities

TM Paravicini, RM Touyz - Diabetes care, 2008 - Am Diabetes Assoc
Reactive oxygen species (ROS) influence many physiological processes including host
defense, hormone biosynthesis, fertilization, and cellular signaling. Increased ROS …

[HTML][HTML] New insights into insulin: The anti-inflammatory effect and its clinical relevance

Q Sun, J Li, F Gao - World journal of diabetes, 2014 - ncbi.nlm.nih.gov
Hyperglycemia, a commonly exhibited metabolic disorder in critically ill patients, activates
the body's inflammatory defense mechanism, causing the waterfall release of numerous …

Hyperglycemia and acute coronary syndrome: a scientific statement from the American Heart Association Diabetes Committee of the Council on Nutrition, Physical …

P Deedwania, M Kosiborod, E Barrett, A Ceriello… - Circulation, 2008 - Am Heart Assoc
Hyperglycemia is common and associated with markedly increased mortality rates in
patients hospitalized with acute coronary syndromes (ACS). Despite the fact that several …

Proinflammatory cytokines, markers of cardiovascular risks, oxidative stress, and lipid peroxidation in patients with hyperglycemic crises

FB Stentz, GE Umpierrez, R Cuervo, AE Kitabchi - Diabetes, 2004 - Am Diabetes Assoc
Acute and chronic hyperglycemia are proinflammatory states, but the status of
proinflammatory cytokines and markers of oxidative stress and cardiovascular risks is not …

Inflamed adipose tissue: a culprit underlying the metabolic syndrome and atherosclerosis

B Gustafson, A Hammarstedt… - … , and vascular biology, 2007 - Am Heart Assoc
The metabolic syndrome is associated with a dysregulated adipose tissue; in part a
consequence of adipose cell enlargement and the associated infiltration of macrophages …