Sex differences in depression: Insights from clinical and preclinical studies

RS Eid, AR Gobinath, LAM Galea - Progress in neurobiology, 2019 - Elsevier
Depression represents a global mental health concern, and disproportionally affects women
as they are twice more likely to be diagnosed than men. In this review, we provide a …

Sex differences in stress-related psychiatric disorders: neurobiological perspectives

DA Bangasser, RJ Valentino - Frontiers in neuroendocrinology, 2014 - Elsevier
Stress is associated with the onset and severity of several psychiatric disorders that occur
more frequently in women than men, including posttraumatic stress disorder (PTSD) and …

Sex-specific transcriptional signatures in human depression

B Labonté, O Engmann, I Purushothaman, C Menard… - Nature medicine, 2017 - nature.com
Major depressive disorder (MDD) is a leading cause of disease burden worldwide. While the
incidence, symptoms and treatment of MDD all point toward major sex differences, the …

[HTML][HTML] Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue

L Dion-Albert, A Cadoret, E Doney… - Nature …, 2022 - nature.com
Prevalence, symptoms, and treatment of depression suggest that major depressive
disorders (MDD) present sex differences. Social stress-induced neurovascular pathology is …

Neuronal connectivity in major depressive disorder: a systematic review

K Helm, K Viol, TM Weiger, PA Tass… - Neuropsychiatric …, 2018 - Taylor & Francis
Background The causes of major depressive disorder (MDD), as one of the most common
psychiatric disorders, still remain unclear. Neuroimaging has substantially contributed to …

[HTML][HTML] Cognitive impairment and depression: meta-analysis of structural magnetic resonance imaging studies

L Zackova, M Jani, M Brazdil, YS Nikolova… - NeuroImage: Clinical, 2021 - Elsevier
Longitudinal comorbidity of depression and cognitive impairment has been reported by
number of epidemiological studies but the underlying mechanisms explaining the link …

Epigenetic mechanisms of major depression: targeting neuronal plasticity

S Uchida, H Yamagata, T Seki… - Psychiatry and clinical …, 2018 - Wiley Online Library
Major depressive disorder is one of the most common mental illnesses as it affects more
than 350 million people globally. Major depressive disorder is etiologically complex and …

[HTML][HTML] Regional gene expression signatures are associated with sex-specific functional connectivity changes in depression

A Talishinsky, J Downar, PE Vértes, J Seidlitz… - Nature …, 2022 - nature.com
The neural substrates of depression may differ in men and women, but the underlying
mechanisms are incompletely understood. Here, we show that depression is associated with …

Causes and consequences of diagnostic heterogeneity in depression: paths to discovering novel biological depression subtypes

CJ Lynch, FM Gunning, C Liston - Biological psychiatry, 2020 - Elsevier
Depression is a highly heterogeneous syndrome that bears only modest correlations with its
biological substrates, motivating a renewed interest in rethinking our approach to …

Brain structure links trait creativity to openness to experience

W Li, X Li, L Huang, X Kong, W Yang… - Social cognitive and …, 2015 - academic.oup.com
Creativity is crucial to the progression of human civilization and has led to important
scientific discoveries. Especially, individuals are more likely to have scientific discoveries if …