The human genetic epidemiology of COVID-19
Human genetics can inform the biology and epidemiology of coronavirus disease 2019
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …
HIV-1 and human genetic variation
PJ McLaren, J Fellay - Nature Reviews Genetics, 2021 - nature.com
Over the past four decades, research on the natural history of HIV infection has described
how HIV wreaks havoc on human immunity and causes AIDS. HIV host genomic research …
how HIV wreaks havoc on human immunity and causes AIDS. HIV host genomic research …
Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine immunogenicity
varies between individuals, and immune responses correlate with vaccine efficacy. Using …
varies between individuals, and immune responses correlate with vaccine efficacy. Using …
Meta-analysis fine-mapping is often miscalibrated at single-variant resolution
Meta-analysis is pervasively used to combine multiple genome-wide association studies
(GWASs). Fine-mapping of meta-analysis studies is typically performed as in a single-cohort …
(GWASs). Fine-mapping of meta-analysis studies is typically performed as in a single-cohort …
Pan-UK Biobank GWAS improves discovery, analysis of genetic architecture, and resolution into ancestry-enriched effects
Large biobanks, such as the UK Biobank (UKB), enable massive phenome by genome-wide
association studies that elucidate genetic etiology of complex traits. However, individuals …
association studies that elucidate genetic etiology of complex traits. However, individuals …
Africa-specific human genetic variation near CHD1L associates with HIV-1 load
PJ McLaren, I Porreca, G Iaconis, HP Mok… - Nature, 2023 - nature.com
HIV-1 remains a global health crisis, highlighting the need to identify new targets for
therapies. Here, given the disproportionate HIV-1 burden and marked human genome …
therapies. Here, given the disproportionate HIV-1 burden and marked human genome …
Genetic swamping of the critically endangered Scottish wildcat was recent and accelerated by disease
J Howard-McCombe, A Jamieson, A Carmagnini… - Current Biology, 2023 - cell.com
The European wildcat population in Scotland is considered critically endangered as a result
of hybridization with introduced domestic cats, 1, 2 though the time frame over which this …
of hybridization with introduced domestic cats, 1, 2 though the time frame over which this …
A deep learning method for HLA imputation and trans-ethnic MHC fine-mapping of type 1 diabetes
Conventional human leukocyte antigen (HLA) imputation methods drop their performance
for infrequent alleles, which is one of the factors that reduce the reliability of trans-ethnic …
for infrequent alleles, which is one of the factors that reduce the reliability of trans-ethnic …
HLA imputation and its application to genetic and molecular fine-mapping of the MHC region in autoimmune diseases
Variations of human leukocyte antigen (HLA) genes in the major histocompatibility complex
region (MHC) significantly affect the risk of various diseases, especially autoimmune …
region (MHC) significantly affect the risk of various diseases, especially autoimmune …
Rapid genotype imputation from sequence with reference panels
Inexpensive genotyping methods are essential to modern genomics. Here we present
QUILT, which performs diploid genotype imputation using low-coverage whole-genome …
QUILT, which performs diploid genotype imputation using low-coverage whole-genome …