Radiation therapy forms one of the building blocks of the multi-disciplinary management of
patients with brain tumors. Improved survival following radiation therapy may come with a …

The nucleotide excision repair (NER) pathway is activated in response to a broad spectrum
of DNA lesions, including bulky lesions induced by platinum-based chemotherapeutic …

The excision repair cross-complementation group 1 (ERCC1) enzyme plays a rate-limiting
role in the nucleotide excision repair pathway and is associated with resistance to platinum …

Platinum agents cause DNA cross-linking. Nucleotide excision repair genes play a key role
in DNA damage repair. This study aims to investigate whether polymorphisms in these …

PURPOSE: Individual variability in radiosensitivity is large in cancer patients. Single
nucleotide polymorphisms (SNPs) in genes involved in DNA repair and in protection against …

Radiation therapy is a key modality in the treatment of cancer. Substantial progress has
been made in unraveling the molecular events which underpin the responses of malignant …

Personalized medicine based on predictive markers linked to drug response, it is hoped, will
lead to improvements in outcomes and avoidance of unnecessary treatment in squamous …

Cells experience both endogenous and exogenous DNA damage daily. To maintain
genome integrity and suppress tumorigenesis, individuals have evolutionarily acquired a …

We assessed whether expression of excision repair cross-complementation group 1
(ERCC1) and/or thymidylate synthase (TS) can predict clinical outcome after preoperative …

Head and neck cancer (HNC) patients have variable prognoses even within the same
clinical stage and while receiving similar treatments. The number of studies of genetic …