The extracellular matrix (ECM) is an essential component of the heart that imparts
fundamental cellular processes during organ development and homeostasis. Most …

The term 'mechanosensation'describes the capacity of cells to translate mechanical stimuli
into the coordinated regulation of intracellular signals, cellular function, gene expression …

To overcome chemotherapy resistance, novel strategies sensitizing cancer cells to
chemotherapy are required. Here, we screen the lysyl-oxidase (LOX) family to clarify its …

Copper is an essential trace metal element that significantly affects human physiology and
pathology by regulating various important biological processes, including mitochondrial …

Extracellular matrix (ECM) remodeling occurs in response to various cardiac insults
including infarction, pressure overload and dilated myopathies. Each type of remodeling …

Atrial fibrillation (AF), the most common cardiac arrhythmia worldwide, is driven by complex
mechanisms that differ between subgroups of patients. This complexity is apparent from the …

Cardiac fibrosis is characterized by a maladaptive remodeling of the myocardium, which is
controlled by various inflammatory pathways and cytokines. This remodeling is …

Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide, with an unmet
therapeutic need. Fibrotic remodeling, in which collagen-producing atrial fibroblasts play a …

Introduction Myocardial fibrosis and cardiac dysfunction are the main characteristics of
diabetic heart disease. However, the molecular mechanisms underlying diabetic myocardial …

Cardiac fibrosis is characterized by excessive deposition of extracellular matrix proteins and
myofibroblast differentiation. Our previous findings have implicated resistin in cardiac …