In the era of COVID-19, understanding how our immune system responds to viral infections
is more pertinent than ever. Immunodeficiencies with very low or absent B cells offer a …

Studies of ancient DNA have transformed our understanding of human evolution.
Paleogenomics can also reveal historic and prehistoric agents of disease, including …

Human herpes simplex virus 1 (HSV-1), a life-long infection spread by oral contact, infects a
majority of adults globally. Phylogeographic clustering of sampled diversity into European …

Systemic lupus erythematosus (SLE) characterized by immune dysfunction is possibly more
vulnerable to herpes simplex virus (HSV) infection. The infection has been intensively …

Free spread is a classical mode for mammalian virus transmission. However, the efficiency
of this transmission approach is generally low as there are structural barriers or …

Tissue-based T cells are important effectors in the prevention and control of mucosal viral
infections; less is known about tissue-based B cells. We demonstrate that B cells and …

Multiple failed herpes simplex virus (HSV) vaccine candidates induce robust neutralizing
antibody (Ab) responses in clinical trials, raising the hypothesis that Fc-domain-dependent …

A majority of the world's population is infected with HSV-1, highlighting the need for vaccines
that are effective in HSV-1-seropositive hosts. We established a superinfection model by …

Herpes simplex viruses (HSV) are common human pathogens with a combined global
seroprevalence of 90% in the adult population. HSV‐1 causes orofacial herpes but can …

Reactivation of herpes simplex virus 1 (HSV-1) from latently infected neurons of the
trigeminal ganglia (TG) leads to blinding recurrent herpetic disease in symptomatic (SYMP) …