Fourteen years have passed since nuclear factor-κB (NF-κB) was first shown to serve as a
molecular lynchpin that links persistent infections and chronic inflammation to increased …

NF-κB transcription factors are critical regulators of immunity, stress responses, apoptosis
and differentiation. A variety of stimuli coalesce on NF-κB activation, which can in turn …

Inflammation is a multicomponent response to tissue stress, injury and infection, and a
crucial point of its control is at the level of gene transcription. The inducible inflammatory …

Signalling by Toll-like receptors (TLRs) involves five adaptor proteins known as MyD88,
MAL, TRIF, TRAM and SARM. Recent insights have revealed additional functions for MyD88 …

Nuclear factor (NF)-κB and inhibitor of NF-κB kinase (IKK) proteins regulate many
physiological processes, including the innate-and adaptive-immune responses, cell death …

TAK-242 (resatorvid), a small-molecule–specific inhibitor of Toll-like receptor (TLR) 4
signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by …

The interferon-regulatory factor (IRF) family of transcription factors was initially found to be
involved in the induction of genes that encode type I interferons. IRFs have now been shown …

An understanding of lipopolysaccharide (LPS) signal transduction is a key goal in the effort
to provide a molecular basis for the lethal effect of LPS during septic shock and point the …

Background Nonalcoholic fatty liver disease (NAFLD) is a common result of obesity and
metabolic syndrome. Hepatocyte injury and metabolic disorders are hallmarks of NAFLD …

Stimulus-induced nuclear factor-κB (NF-κB) activity, the central mediator of inflammatory
responses and immune function, comprises a family of dimeric transcription factors that …