Regulating striated muscle contraction: Through thick and thin
E Brunello, L Fusi - Annual Review of Physiology, 2024 - annualreviews.org
Force generation in striated muscle is primarily controlled by structural changes in the actin-
containing thin filaments triggered by an increase in intracellular calcium concentration …
containing thin filaments triggered by an increase in intracellular calcium concentration …
Reassessing the unifying hypothesis for hypercontractility caused by myosin mutations in hypertrophic cardiomyopathy
JA Spudich, N Nandwani, J Robert-Paganin… - The EMBO …, 2024 - embopress.org
Human β-cardiac myosin exists in an ON-state where both myosin heads are accessible for
interaction with actin, and an OFF-state where the heads are folded back onto their own …
interaction with actin, and an OFF-state where the heads are folded back onto their own …
Myosin-binding protein C regulates the sarcomere lattice and stabilizes the OFF states of myosin heads
Muscle contraction is produced via the interaction of myofilaments and is regulated so that
muscle performance matches demand. Myosin-binding protein C (MyBP-C) is a long and …
muscle performance matches demand. Myosin-binding protein C (MyBP-C) is a long and …
Myosin in autoinhibited off state(s), stabilized by mavacamten, can be recruited in response to inotropic interventions
W Ma, CL Del Rio, L Qi, M Prodanovic… - Proceedings of the …, 2024 - National Acad Sciences
Mavacamten is a FDA-approved small-molecule therapeutic designed to regulate cardiac
function at the sarcomere level by selectively but reversibly inhibiting the enzymatic activity …
function at the sarcomere level by selectively but reversibly inhibiting the enzymatic activity …
Danicamtiv increases myosin recruitment and alters cross-bridge cycling in cardiac muscle
BACKGROUND: Modulating myosin function is a novel therapeutic approach in patients with
cardiomyopathy. Danicamtiv is a novel myosin activator with promising preclinical data that …
cardiomyopathy. Danicamtiv is a novel myosin activator with promising preclinical data that …
Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function
Missense variant Ile79Asn in human cardiac troponin T (cTnT-I79N) has been associated
with hypertrophic cardiomyopathy and sudden cardiac arrest in juveniles. cTnT-I79N is …
with hypertrophic cardiomyopathy and sudden cardiac arrest in juveniles. cTnT-I79N is …
Multiscale modeling shows how 2'-deoxy-ATP rescues ventricular function in heart failure
2'-deoxy-ATP (dATP) improves cardiac function by increasing the rate of crossbridge cycling
and Ca 2+ transient decay. However, the mechanisms of these effects and how therapeutic …
and Ca 2+ transient decay. However, the mechanisms of these effects and how therapeutic …
Embryonic Exposure to Organophosphate Flame Retardants (OPFRs) Differentially Induces Cardiotoxicity in Rare Minnow (Gobiocypris rarus)
X Hong, L Yuan, X Zhao, Y Shan, T Qin… - … Science & Technology, 2024 - ACS Publications
Organophosphorus flame retardants (OPFRs) such as triphenyl phosphate (TPHP) and tris
(1, 3-dichloro-2-propyl) phosphate (TDCIPP) were reported to impair cardiac function in fish …
(1, 3-dichloro-2-propyl) phosphate (TDCIPP) were reported to impair cardiac function in fish …
The biochemically defined super relaxed state of myosin—a paradox
The biochemical SRX (super-relaxed) state of myosin has been defined as a low ATPase
activity state. This state can conserve energy when the myosin is not recruited for muscle …
activity state. This state can conserve energy when the myosin is not recruited for muscle …
The structural OFF and ON states of myosin can be decoupled from the biochemical super-and disordered-relaxed states
There is a growing awareness that both thick-filament and classical thin-filament regulations
play central roles in modulating muscle contraction. Myosin ATPase assays have …
play central roles in modulating muscle contraction. Myosin ATPase assays have …