The senescence accelerate mouse P8 (SAMP8) is an excellent model of early learning and
memory problems. A number of studies have shown that it has cholinergic deficits, oxidative …

Peptide nucleic acids (PNAs) are DNA analogs that hybridize to complementary nucleic
sequences with high affinity and stability. In our previous work, we showed that a PNA …

Neurotensin (NT) is a 13 amino acid neuropeptide that is found in the central nervous
system and in the gastrointestinal tract. In brain, this peptide is prominently associated …

Circadian rhythms influence cocaine‐seeking behavior in rats, and this behavior may be
mediated by variability in the rate of extracellular dopamine clearance across the day: night …

In this work, we have targeted positions 18–38 of the human galanin receptor type 1 (GalR1)
mRNA coding sequence with different peptide nucleic acid (PNA) oligomers. This region has …

Alzheimer's disease (AD) is a neurodegenerative disease associated with increased
expression of amyloid precursor protein (APP) and the deposition of its proteolytic cleavage …

Peptide nucleic acids (PNAs) are uncharged DNA analogs that hybridize to complementary
sequences with high affinity and stability. We previously showed that PNAs, after …

The amyloid precursor protein (APP) and its proteolytic cleavage products, the amyloid β
peptides, have been implicated as a cause of Alzheimer's disease. Peptide nucleic acids …

BACKGROUND CONTEXT: Variability in human pain experience appears to be at least
partially determined by genetic inheritance. To the extent that awareness of individual pain …

To determine the effectiveness of peptide nucleic acids (PNAs) in vivo, we designed and
synthesized PNAs antisense to the mu receptor, the molecular target of morphine for …