On the road to cancer: aneuploidy and the mitotic checkpoint
GJPL Kops, BAA Weaver, DW Cleveland - Nature Reviews Cancer, 2005 - nature.com
Abnormal chromosome content—also known as aneuploidy—is the most common
characteristic of human solid tumours. It has therefore been proposed that aneuploidy …
characteristic of human solid tumours. It has therefore been proposed that aneuploidy …
The anaphase promoting complex/cyclosome: a machine designed to destroy
JM Peters - Nature reviews Molecular cell biology, 2006 - nature.com
The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has
essential functions in and outside the eukaryotic cell cycle. It is the most complex molecular …
essential functions in and outside the eukaryotic cell cycle. It is the most complex molecular …
[HTML][HTML] NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis
Accelerated glycolysis is the main metabolic change observed in cancer, but the underlying
molecular mechanisms and their role in cancer progression remain poorly understood …
molecular mechanisms and their role in cancer progression remain poorly understood …
Ubiquitous activation of Ras and Jak/Stat pathways in human HCC
DF Calvisi, S Ladu, A Gorden, M Farina, EA Conner… - Gastroenterology, 2006 - Elsevier
Background & Aims: Although the natural history and pathologic characteristics of human
hepatocellular carcinoma (HCC) are well documented, the molecular pathogenesis of HCC …
hepatocellular carcinoma (HCC) are well documented, the molecular pathogenesis of HCC …
Cubism and the cell cycle: the many faces of the APC/C
J Pines - Nature reviews Molecular cell biology, 2011 - nature.com
One does not often look to analytic cubism for insights into the control of the cell cycle, but
Pablo Picasso beautifully encapsulated the fundamentals when he said that “every act of …
Pablo Picasso beautifully encapsulated the fundamentals when he said that “every act of …
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
EHY Chan, M Nousiainen, RB Chalamalasetty… - Oncogene, 2005 - nature.com
Originally identified in Drosophila melanogaster, the Warts (Wts)/Lats protein kinase has
been proposed to function with two other Drosophila proteins, Hippo (Hpo) and Salvador …
been proposed to function with two other Drosophila proteins, Hippo (Hpo) and Salvador …
Targeting Cdc20 as a novel cancer therapeutic strategy
Abstract The Anaphase Promoting Complex (APC, also called APC/C) regulates cell cycle
progression by forming two closely related, but functionally distinct E3 ubiquitin ligase sub …
progression by forming two closely related, but functionally distinct E3 ubiquitin ligase sub …
Intracellular signalling controlling integrin activation in lymphocytes
T Kinashi - Nature Reviews Immunology, 2005 - nature.com
Since the discovery that integrins at the surface of lymphocytes undergo dynamic changes in
their adhesive activity after stimulation through the T-cell receptor or stimulation with …
their adhesive activity after stimulation through the T-cell receptor or stimulation with …
[HTML][HTML] Breaking bad: how viruses subvert the cell cycle
Y Fan, S Sanyal, R Bruzzone - Frontiers in cellular and infection …, 2018 - frontiersin.org
Interactions between the host and viruses during the course of their co-evolution have not
only shaped cellular function and the immune system, but also the counter measures …
only shaped cellular function and the immune system, but also the counter measures …
The RASSF1A tumor suppressor
H Donninger, MD Vos, GJ Clark - Journal of cell science, 2007 - journals.biologists.com
RASSF1A (Ras association domain family 1 isoform A) is a recently discovered tumor
suppressor whose inactivation is implicated in the development of many human cancers …
suppressor whose inactivation is implicated in the development of many human cancers …