Abnormal chromosome content—also known as aneuploidy—is the most common
characteristic of human solid tumours. It has therefore been proposed that aneuploidy …

The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has
essential functions in and outside the eukaryotic cell cycle. It is the most complex molecular …

Accelerated glycolysis is the main metabolic change observed in cancer, but the underlying
molecular mechanisms and their role in cancer progression remain poorly understood …

Background & Aims: Although the natural history and pathologic characteristics of human
hepatocellular carcinoma (HCC) are well documented, the molecular pathogenesis of HCC …

One does not often look to analytic cubism for insights into the control of the cell cycle, but
Pablo Picasso beautifully encapsulated the fundamentals when he said that “every act of …

Originally identified in Drosophila melanogaster, the Warts (Wts)/Lats protein kinase has
been proposed to function with two other Drosophila proteins, Hippo (Hpo) and Salvador …

Abstract The Anaphase Promoting Complex (APC, also called APC/C) regulates cell cycle
progression by forming two closely related, but functionally distinct E3 ubiquitin ligase sub …

Since the discovery that integrins at the surface of lymphocytes undergo dynamic changes in
their adhesive activity after stimulation through the T-cell receptor or stimulation with …

Interactions between the host and viruses during the course of their co-evolution have not
only shaped cellular function and the immune system, but also the counter measures …

RASSF1A (Ras association domain family 1 isoform A) is a recently discovered tumor
suppressor whose inactivation is implicated in the development of many human cancers …