Recent research into the pathophysiology and treatment of atopic dermatitis (AD) has shown
notable progress. An increasing number of aspects of the immune system are being …

abstract Atopic dermatitis is a skin disorder caused by skin dryness and barrier dysfunction,
resulting in skin inflammation and chronic itch (or pruritus). The pathogenesis of atopic …

In addition to its canonical function of protection from pathogens, the immune system can
also alter behaviour,. The scope and mechanisms of behavioural modifications by the …

The physiological functions of mast cells remain largely an enigma. In the context of barrier
damage, mast cells are integrated in type 2 immunity and, together with immunoglobulin E …

Atopic dermatitis (AD) is a common, chronic-relapsing inflammatory skin disease with
significant disease burden. Genetic and environmental trigger factors contribute to AD …

Itch is an unpleasant sensation that evokes a desire to scratch. The skin barrier is constantly
exposed to microbes and their products. However, the role of microbes in itch generation is …

Aeroallergen sensing by airway epithelial cells triggers pathogenic immune responses
leading to type 2 inflammation, the hallmark of chronic airway diseases such as asthma. Tuft …

Sensory neurons in the dorsal root ganglion (DRG) and trigeminal ganglion (TG) are
specialized to detect and transduce diverse environmental stimuli to the central nervous …

Atopic dermatitis (AD) is a multifaceted, chronic relapsing inflammatory skin disease that
affects people of all ages. It is characterized by chronic eczema, constant pruritus, and …

Dorsal root ganglia (DRG) somatosensory neurons detect mechanical, thermal, and
chemical stimuli acting on the body. Achieving a holistic view of how different DRG neuron …