Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

During the last 10-15 years, cytochrome P450 (CYP) 2C8 has emerged as an important drug-
metabolizing enzyme. CYP2C8 is highly expressed in human liver and is known to …

Cardiovascular diseases (CVDs) remain the leading cause of death in the developed
countries. Taking into account the mounting evidence about the role of cytochrome P450 …

Metabolism of the antimalarial drug amodiaquine (AQ) into its primary metabolite, N‐
desethylamodiaquine, is mediated by CYP2C8. We studied the frequency of CYP2C8 …

The use of diclofenac is associated with rare but severe drug-induced liver injury (DILI) in a
very small number of patients. The factors which predispose susceptible patients to …

OBJECTIVES:(i) To define the incidence of alleles CYP2C8* 1 to* 5 in a Spanish
population;(ii) to test the impact of such alleles, and those of CYP2C9, on the metabolism of …

Malaria is a major infectious disease. In the last 10 years it has killed more than 20 million
people, mainly small children in Africa. The highly efficacious artemisinine combination …

Background: The cytochrome P450 enzymes (CYP) play an important role in the metabolism
of many therapeutic agents. The activities of different enzymes exhibit variability in different …

The impact of biogeographical ancestry, self-reported 'race/color'and geographical origin on
the frequency distribution of 10 CYP2C functional polymorphisms (CYP2C8* 2,* 3,* 4 …

The pharmacokinetics of ibuprofen enantiomers and its chiral metabolites, namely (R, S)-29-
hydroxyibuprofen and (RR, RS, SR, SS)-29-carboxyibuprofen, was studied in healthy …