While alcohol use disorder (AUD) is a highly heritable psychiatric disease, efforts to
elucidate that heritability by examining genetic variation (eg, single nucleotide …

Foetal alcohol spectrum disorders (FASDs) are a leading cause of developmental disability.
Prenatal alcohol use is the sole necessary cause of FASD, but it is not always sufficient …

Background Alcohol consumption and tobacco exposure during pregnancy are hazardous
behaviours which are increasing significantly in low and middle-income countries, including …

The neuropeptide orexin/hypocretin (OX), while largely transcribed within the hypothalamus,
is released throughout the brain to affect complex behaviors. Primarily through the …

Single-cell transcriptomic platforms provide an opportunity to map an organism's response
to environmental cues with high resolution. Here, we applied single-nucleus RNA …

Fetal alcohol spectrum disorder (FASD) is a multifaceted disability, characterized not only by
brain-and body-based challenges, but also high rates of environmental adversity, lifelong …

The unabated rise in obesity prevalence during the last 40 years has spurred substantial
interest in understanding the reasons for this epidemic. Studies in mice and humans have …

Alcohol has pleiotropic effects across multiple organ systems, including brain,
cardiovascular, endocrine, immune, musculoskeletal, and gastrointestinal systems …

There are numerous clinical and pre-clinical studies showing that exposure of the embryo to
ethanol markedly affects neuronal development and stimulates alcohol drinking and related …

Previously it has been shown that fetal alcohol exposure increases the stress response
partly due to lowering stress regulatory proopiomelanocortin (Pomc) gene expression in the …