Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …

SLE is characterised by an activation of the interferon (IFN) system, which leads to an
increased expression of IFN-regulated genes. The reasons behind the IFN signature in SLE …

Highlights•Type I IFN is implicated in SLE pathogenesis by multiple lines of evidence,
including genetics and induction of SLE by IFN treatment.•Nucleic-acid sensing pathways …

Investigations of patients with systemic lupus erythematosus have applied insights from
studies of the innate immune response to define IFN-I, with IFN-α as the dominant mediator …

Immune responses differ between women and men, and type I interferon (IFN) responses
following Toll-like receptor 7 (TLR7) stimulation are higher in women. The precise …

Objective The role of interferon‐α (IFNα) in the pathogenesis of systemic lupus
erythematosus (SLE) is strongly supported by gene expression studies. The aim of this study …

▪ Abstract Type 1 interferon-(α, β, ω)-producing cells (IPCs), also known as plasmacytoid
dendritic cell precursors (pDCs), represent 0.2%–0.8% of peripheral blood mononuclear …

Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease that causes
damage to multiple organ systems. Despite decades of research and available murine …

Aicardi-Goutières syndrome is a mendelian mimic of congenital infection and also shows
overlap with systemic lupus erythematosus at both a clinical and biochemical level. The …

Plasmacytoid dendritic cells (pDCs) have long been implicated in the pathogenesis of lupus.
However, this conclusion has been largely based on a correlative link between the copious …