The apicomplexan family of pathogens, which includes Plasmodium spp. and Toxoplasma
gondii, are primarily obligate intracellular parasites and invade multiple cell types. These …

Highlights•Plasmodium and Toxoplasma zooites share common mechanisms for host cell
invasion.•Invasion involves apical organelle release, tight junction formation and movement …

Aminopyrazoles are a new class of antimalarial compounds identified in a cellular
antiparasitic screen with potent activity against Plasmodium falciparum asexual and sexual …

Constrained α-helical peptides are an exciting class of molecule designed to disrupt protein–
protein interactions (PPIs) at a surface-exposed helix binding site. Complexes that engage …

The phylum Apicomplexa comprises over 5000 intracellular protozoan parasites, including
Plasmodium and Toxoplasma, that are clinically important pathogens affecting humans and …

Many diverse myosin classes can be expressed using the baculovirus/Sf9 insect cell
expression system, whereas others have been recalcitrant. We hypothesized that most …

Myosin B (MyoB) is one of the two short class XIV myosins encoded in the Plasmodium
genome. Class XIV myosins are characterized by a catalytic" head," a modified" neck," and …

Gliding, a type of motility based on an actin-myosin motor, is specific to apicomplexan
parasites. Myosin A binds two light chains which further interact with glideosome associated …

Parasites from the genus Plasmodium are the causative agents of malaria. The mobility,
infectivity, and ultimately pathogenesis of Plasmodium falciparum rely on a macromolecular …

Motility is a vital feature of the complex life cycle of Plasmodium falciparum, the
apicomplexan parasite that causes human malaria. Processes such as host cell invasion are …