Betulinic acid (BA) is a widely available plant-derived triterpene with reported activity against
cancer cells of neuroectodermal origin and leukaemias. Treatment with BA was shown to …

Protein acetyltransferases and deacetylases have been implicated in oncogenesis,
apoptosis and cell cycle regulation. Most of the protein acetyltransferases described …

Acquired resistance to mechanisms of programmed cell death is one of the hallmarks of
cancer. Human melanoma, in advanced stage, is hardly curable, due to development of …

Plumbagin [5-hydroxy-2-methyl-1, 4-naphthaquinone] is a well-known plant derived
anticancer lead compound. Several efforts have been made to synthesize its analogs and …

Fagonia indica is a small spiny shrub of great ethnopharmacological importance in folk
medicine. The aqueous decoction of aerial parts is a popular remedy against various skin …

Recent clinical trials have documented that selenium significantly reduces the incidence of
clinical prostate cancer. However, nothing is clearly known about the underlying molecular …

Melanoma is a deadly form of cancer characterized by remarkable therapy resistance.
Analyzing the transcriptome of MAPK inhibitor sensitive-and resistant-melanoma, we …

In this comprehensive study on the caspase-mediated apoptosis-inducing effect of 51
substituted phenols in a murine leukemia cell line (L1210), we determined the …

Radiation therapy is routinely prescribed for high-grade malignant gliomas. However, the
efficacy of this therapeutic modality is often limited by the occurrence of radioresistance …

Phenol and its congeners are known to induce caspase‐mediated apoptosis activity and
cytotoxicity on various cancer cell lines. Apoptosis, scavenging of radicals, antioxidant, and …