A comprehensive insight on ocular pharmacokinetics
The eye is a distinctive organ with protective anatomy and physiology. Several
pharmacokinetics compartment models of ocular drug delivery have been developed for …
pharmacokinetics compartment models of ocular drug delivery have been developed for …
Overcoming the intestinal barrier: a look into targeting approaches for improved oral drug delivery systems
Oral drug administration is one of the most preferred and simplest routes among both
patients and formulation scientists. Nevertheless, orally delivery of some of the most widely …
patients and formulation scientists. Nevertheless, orally delivery of some of the most widely …
Topical ophthalmic lipid nanoparticle formulations (SLN, NLC) of indomethacin for delivery to the posterior segment ocular tissues
SP Balguri, GR Adelli, S Majumdar - European Journal of Pharmaceutics …, 2016 - Elsevier
Purpose The objective of the present study was to formulate indomethacin (IN)-loaded solid
lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) and to investigate their …
lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) and to investigate their …
Sodium-coupled glucose transport, the SLC5 family, and therapeutically relevant inhibitors: from molecular discovery to clinical application
G Gyimesi, J Pujol-Giménez, Y Kanai… - Pflügers Archiv-European …, 2020 - Springer
Sodium glucose transporters (SGLTs) belong to the mammalian solute carrier family SLC5.
This family includes 12 different members in human that mediate the transport of sugars …
This family includes 12 different members in human that mediate the transport of sugars …
Transporter-mediated drug delivery
G Gyimesi, MA Hediger - Molecules, 2023 - mdpi.com
Transmembrane transport of small organic and inorganic molecules is one of the
cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier …
cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier …
Optimization, stabilization, and characterization of amphotericin B loaded nanostructured lipid carriers for ocular drug delivery
The current study sought to formulate, optimize, and stabilize amphotericin B (AmB) loaded
PEGylated nanostructured lipid carriers (NLC) and to study its ocular biodistribution …
PEGylated nanostructured lipid carriers (NLC) and to study its ocular biodistribution …
Prodrugs and nanomicelles to overcome ocular barriers for drug penetration
Introduction Ocular barriers hinder drug delivery and reduce drug bioavailability. This article
focuses on enhancing drug absorption across the corneal and conjunctival epithelium. Both …
focuses on enhancing drug absorption across the corneal and conjunctival epithelium. Both …
Lipid nanoparticles for ocular gene delivery
Y Wang, A Rajala, RVS Rajala - Journal of functional biomaterials, 2015 - mdpi.com
Lipids contain hydrocarbons and are the building blocks of cells. Lipids can naturally form
themselves into nano-films and nano-structures, micelles, reverse micelles, and liposomes …
themselves into nano-films and nano-structures, micelles, reverse micelles, and liposomes …
Design and synthesis of sulfonamides incorporating a biotin moiety: Carbonic anhydrase inhibitory effects, antiproliferative activity and molecular modeling studies
Sulfonamides constitute an important class of classical carbonic anhydrase (CA, EC 4.2. 1.1)
inhibitors. Herein we have accomplished the conjugation of biotin with an ample number of …
inhibitors. Herein we have accomplished the conjugation of biotin with an ample number of …
Aqueous nanomicellar formulation for topical delivery of biotinylated lipid prodrug of acyclovir: formulation development and ocular biocompatibility
AD Vadlapudi, K Cholkar, RK Vadlapatla… - Journal of ocular …, 2014 - liebertpub.com
Purpose: The objective of this study was to develop a clear, aqueous nanomicellar
formulation and evaluate its in vitro ocular biocompatibility as a novel carrier for topical …
formulation and evaluate its in vitro ocular biocompatibility as a novel carrier for topical …