Inhibitors and PROTACs of CDK2: challenges and opportunities
Y Zeng, X Ren, P Jin, Z Fan, M Liu… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Abundant evidence suggests that the overexpression of CDK2-cyclin A/E
complex disrupts normal cell cycle regulation, leading to uncontrolled proliferation of cancer …
complex disrupts normal cell cycle regulation, leading to uncontrolled proliferation of cancer …
[HTML][HTML] Mixtures of Three Mortaparibs with Enhanced Anticancer, Anti-Migration, and Antistress Activities: Molecular Characterization in p53-Null Cancer Cells
Simple Summary The Hsp70 family stress chaperone mortalin plays an important role in
carcinogenesis and hence has emerged as a candidate target for cancer drug development …
carcinogenesis and hence has emerged as a candidate target for cancer drug development …
Toward Precision Oncology: The Role of TPD in Targeting CDK2 and Beyond
RB Kargbo - ACS Medicinal Chemistry Letters, 2024 - ACS Publications
Advancements in targeted protein degradation (TPD) technologies are spearheading a new
era in precision oncology, offering unprecedented avenues for tackling key oncogenic …
era in precision oncology, offering unprecedented avenues for tackling key oncogenic …
AI in Pharma: Transforming Drug Discovery and Strategic Management with MYC-Modulating Compounds and BET Protein Inhibitors
RB Kargbo - ACS Medicinal Chemistry Letters, 2024 - ACS Publications
The landscape of pharmaceutical R&D is being reshaped by the synergistic integration of
Artificial Intelligence (AI) and groundbreaking drug discoveries, mainly focusing on MYC …
Artificial Intelligence (AI) and groundbreaking drug discoveries, mainly focusing on MYC …
Combined SET7/9 and CDK4 inhibition act synergistically against osteosarcoma
Y Shi, Z Wang, Y Shao, Q Guang, J Zhang, B Liu… - Biochemical and …, 2024 - Elsevier
Osteosarcoma is the most common malignant bone tumor. It has a poor prognosis because
of a lack of therapeutic targets and strategies. The SET domain-containing lysine-specific …
of a lack of therapeutic targets and strategies. The SET domain-containing lysine-specific …
[引用][C] Mixtures of Three Mortaparibs with Enhanced Anticancer, Anti-Migration, and Antistress Activities: Molecular Characterization in p53-Null Cancer Cells. Cancers …
Mortalin, a member of the Hsp70 family of proteins, is commonly enriched in many types of
cancers. It promotes carcinogenesis and metastasis in multiple ways of which the …
cancers. It promotes carcinogenesis and metastasis in multiple ways of which the …