Quality control in the endoplasmic reticulum: crosstalk between ERAD and UPR pathways
Endoplasmic reticulum (ER)-associated degradation (ERAD) and the unfolded protein
response (UPR) are two key quality-control machineries in the cell. ERAD is responsible for …
response (UPR) are two key quality-control machineries in the cell. ERAD is responsible for …
ER-associated degradation: Protein quality control and beyond
A Ruggiano, O Foresti, P Carvalho - Journal of Cell Biology, 2014 - rupress.org
Even with the assistance of many cellular factors, a significant fraction of newly synthesized
proteins ends up misfolded. Cells evolved protein quality control systems to ensure that …
proteins ends up misfolded. Cells evolved protein quality control systems to ensure that …
Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis
Increased endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) are the
salient features of end-stage liver diseases. Using liver tissues from liver cirrhosis patients …
salient features of end-stage liver diseases. Using liver tissues from liver cirrhosis patients …
New insights into the physiological role of endoplasmic reticulum-associated degradation
Many human diseases are associated with mutations causing protein misfolding and
aggregation in the endoplasmic reticulum (ER). ER-associated degradation (ERAD) is a …
aggregation in the endoplasmic reticulum (ER). ER-associated degradation (ERAD) is a …
[HTML][HTML] Biallelic Cys141Tyr variant of SEL1L is associated with neurodevelopmental disorders, agammaglobulinemia, and premature death
Suppressor of lin-12-like–HMG-CoA reductase degradation 1 (SEL1L-HRD1) ER-
associated degradation (ERAD) plays a critical role in many physiological processes in …
associated degradation (ERAD) plays a critical role in many physiological processes in …
[HTML][HTML] Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders
Recent studies using cell type–specific knockout mouse models have improved our
understanding of the pathophysiological relevance of suppressor of lin-12-like–HMG-CoA …
understanding of the pathophysiological relevance of suppressor of lin-12-like–HMG-CoA …
IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation
Endoplasmic reticulum (ER)-associated degradation (ERAD) represents a principle quality
control mechanism to clear misfolded proteins in the ER; however, its physiological …
control mechanism to clear misfolded proteins in the ER; however, its physiological …
The unfolded protein response, degradation from the endoplasmic reticulum, and cancer
YC Tsai, AM Weissman - Genes & cancer, 2010 - journals.sagepub.com
The endoplasmic reticulum (ER) is an essential organelle involved in many cellular
functions including protein folding and secretion, lipid biosynthesis, and calcium …
functions including protein folding and secretion, lipid biosynthesis, and calcium …
Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling
Ubiquitin ligases (E3s) embedded in the endoplasmic reticulum (ER) membrane regulate
essential cellular activities including protein quality control, calcium flux, and sterol …
essential cellular activities including protein quality control, calcium flux, and sterol …
Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival
Suppressor/Enhancer of Lin-12-like (Sel1L) is an adaptor protein for the E3 ligase
hydroxymethylglutaryl reductase degradation protein 1 (Hrd1) involved in endoplasmic …
hydroxymethylglutaryl reductase degradation protein 1 (Hrd1) involved in endoplasmic …