Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Abstract Histone deacetylase 8 (HDAC8) aberrantly deacetylates histone and non-histone
proteins. These include structural maintenance of chromosome 3 (SMC3) cohesin protein …

Chromatin is dynamically reorganized when DNA replication forks are challenged. However,
the process of epigenetic reorganization and its implication for fork stability is poorly …

Smooth muscle cell (SMC) loss is the characteristic feature in the pathogenesis of aortic
dissection (AD), and ferroptosis is a novel iron-dependent regulated cell death driven by the …

Epigenetic enzymes histone deacetylases (HDACs) are clinically validated anticancer drug
targets which have been studied intensively in the past few decades. Although several drugs …

Histone methyltransferases (HMTs) play a critical role in gene post-translational regulation
and diverse physiological processes, and are implicated in a plethora of human diseases …

Simple Summary Advanced cutaneous melanoma is the most aggressive type of skin cancer
and has variable rates of treatment response. Currently, there are some classes of …

Histone modifications are key factors in chromatin packaging, and are responsible for gene
regulation during cell fate determination and development. Abnormal alterations in histone …

The reversible and precise temporal and spatial regulation of histone lysine
methyltransferases (KMTs) is essential for epigenome homeostasis. The dysregulation of …

A significant advancement in the field of epigenetic drug discovery has been evidenced in
recent years. Epigenetic alterations are hereditary, nevertheless reversible variations to …