Skeletal muscles mainly contribute to the emergence of insulin resistance, impaired glucose
tolerance and the development of type 2 diabetes. Molecular mechanisms that regulate …

Unraveling how cellular signaling is remodeled upon perturbation is crucial for
understanding disease mechanisms and identifying potential drug targets. In this pursuit …

Hepatic glucose metabolism serves dual purposes: maintaining glucose homeostasis and
converting glucose into energy sources; however, the underlying mechanisms are unclear …

Dysregulation of liver metabolism associated with obesity during feeding and fasting leads
to the breakdown of metabolic homeostasis. However, the underlying mechanism remains …

To satisfy both the safety and rapidity of glycemic control, muscles' insulin response must be
bistable, as theoretically predicted. Here, we test the bistability hypothesis by combining …

Diabetes is an epidemic caused by a multitude of factors. Despite the studies attempting to
unravel its mechanism, there is still more to discover about glucose–insulin dynamics. In a …

Understanding complex diseases requires approaches that jointly analyze omic data across
multiple biological layers, including signaling, gene regulation, and metabolism. Existing …

Gene model for the ortholog of Myc (Myc) in the D. eugracilis Apr. 2013 (BCM-
HGSC/Deug_2. 0)(DeugGB2) Genome Assembly (GenBank Accession: GCA_000236325 …