Redox-modulating agents in the treatment of viral infections

P Checconi, M De Angelis, ME Marcocci… - International Journal of …, 2020 - mdpi.com
Viruses use cell machinery to replicate their genome and produce viral proteins. For this
reason, several intracellular factors, including the redox state, might directly or indirectly …

[HTML][HTML] The glutathione system: a new drug target in neuroimmune disorders

G Morris, G Anderson, O Dean, M Berk, P Galecki… - Molecular …, 2014 - Springer
Glutathione (GSH) has a crucial role in cellular signaling and antioxidant defenses either by
reacting directly with reactive oxygen or nitrogen species or by acting as an essential …

Glutathione: Role in oxidative/nitrosative stress, antioxidant defense, and treatments

S Raj Rai, C Bhattacharyya, A Sarkar… - …, 2021 - Wiley Online Library
Glutathione (GSH) is the most abundant cellular tripeptide (L‐γ‐glutamate‐L‐cysteinyl‐
glycine) which is as critical as oxygen and water. This low molecular mass antioxidant has a …

Intracellular redox-modulated pathways as targets for effective approaches in the treatment of viral infection

A Fraternale, C Zara, M De Angelis, L Nencioni… - International Journal of …, 2021 - mdpi.com
Host-directed therapy using drugs that target cellular pathways required for virus lifecycle or
its clearance might represent an effective approach for treating infectious diseases …

Prodrug approach for increasing cellular glutathione levels

I Cacciatore, C Cornacchia, F Pinnen, A Mollica… - Molecules, 2010 - mdpi.com
Reduced glutathione (GSH) is the most abundant non-protein thiol in mammalian cells and
the preferred substrate for several enzymes in xenobiotic metabolism and antioxidant …

GSH and analogs in antiviral therapy

A Fraternale, MF Paoletti, A Casabianca… - Molecular aspects of …, 2009 - Elsevier
Reduced glutathione (GSH) is the most prevalent non-protein thiol in animal cells. Its de
novo and salvage synthesis serves to maintain a reduced cellular environment. GSH is the …

[HTML][HTML] Multiple antimicrobial and immune-modulating activities of cysteamine in infectious diseases

T Alonzi, A Aiello, M Sali, G Delogu, VR Villella… - Biomedicine & …, 2024 - Elsevier
Infectious diseases are a major threat to global health and cause millions of deaths every
year, particularly in developing countries. The emergence of multidrug resistance …

Glutathione and glutathione derivatives in immunotherapy

A Fraternale, S Brundu, M Magnani - Biological chemistry, 2017 - degruyter.com
Reduced glutathione (GSH) is the most prevalent non-protein thiol in animal cells. Its de
novo and salvage synthesis serves to maintain a reduced cellular environment, which is …

The HIV-1 transactivator factor (Tat) induces enterocyte apoptosis through a redox-mediated mechanism

V Buccigrossi, G Laudiero, E Nicastro, E Miele… - PloS one, 2011 - journals.plos.org
The intestinal mucosa is an important target of human immunodeficiency virus (HIV)
infection. HIV virus induces CD4+ T cell loss and epithelial damage which results in …

Design, synthesis and anti-NASH effect evaluation of novel GFT505 derivatives in vitro and in vivo

C Xiang, X Chen, J Yao, N Yang, J Yu, Q Qiu… - European Journal of …, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is emerging as the largest burden of chronic liver
disease worldwide. Nonalcoholic steatohepatitis (NASH) is a progressive form of NAFLD …