Metabolomics: small molecules that matter more

BC Muthubharathi, T Gowripriya, K Balamurugan - Molecular omics, 2021 - pubs.rsc.org
Metabolomics, an analytical study with high-throughput profiling, helps to understand
interactions within a biological system. Small molecules, called metabolites or metabolomes …

Metabolomics in diabetic retinopathy: from potential biomarkers to molecular basis of oxidative stress

Q Jian, Y Wu, F Zhang - Cells, 2022 - mdpi.com
Diabetic retinopathy (DR), the leading cause of blindness in working-age adults, is one of
the most common complications of diabetes mellitus (DM) featured by metabolic disorders …

Metabolomics of various samples advancing biomarker discovery and pathogenesis elucidation for diabetic retinopathy

X Du, L Yang, L Kong, Y Sun, K Shen, Y Cai… - Frontiers in …, 2022 - frontiersin.org
Diabetic retinopathy (DR) is a universal microvascular complication of diabetes mellitus
(DM), which is the main reason for global sight damage/loss in middle-aged and/or older …

Amino acids metabolism in retinopathy: from clinical and basic research perspective

M Xia, F Zhang - Metabolites, 2022 - mdpi.com
Retinopathy, including age-related macular degeneration (AMD), diabetic retinopathy (DR),
and retinopathy of prematurity (ROP), are the leading cause of blindness among seniors …

Circulating metabolites and lipids are associated to diabetic retinopathy in individuals with type 1 diabetes

VR Curovic, T Suvitaival, I Mattila, L Ahonen, K Trošt… - Diabetes, 2020 - Am Diabetes Assoc
Omics-based methods may provide new markers associated to diabetic retinopathy (DR).
We investigated a wide omics panel of metabolites and lipids related to DR in type 1 …

Integrated metabolomics and transcriptomics reveal metabolic patterns in retina of STZ-induced diabetic retinopathy mouse model

R Wang, Q Jian, G Hu, R Du, X Xu, F Zhang - Metabolites, 2022 - mdpi.com
Diabetic retinopathy (DR), as the leading cause of vision loss in the working-age population,
exhibits unique metabolite profiles in human plasma and vitreous. However, those in retina …

Untargeted multiomics approach coupling lipidomics and metabolomics profiling reveals new insights in diabetic retinopathy

P Ancel, JC Martin, E Doukbi, M Houssays… - International Journal of …, 2023 - mdpi.com
Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus (DM) which is
the main cause of vision loss in the working-age population. Currently known risk factors …

A novel approach based on metabolomics coupled with intestinal flora analysis and network pharmacology to explain the mechanisms of action of bekhogainsam …

X Meng, J Ma, AN Kang, SY Kang, HW Jung… - Frontiers in …, 2020 - frontiersin.org
Bekhogainsam decoction (BHID), a representative prescription for the treatment of diabetes
mellitus (DM) and diabetic complications in both traditional Korean and Chinese medicine …

Branched-chain amino acids metabolism and their roles in retinopathy: from relevance to mechanism

X Zhang, M Xia, Y Wu, F Zhang - Nutrients, 2023 - mdpi.com
Retinopathy is one of the leading causes of irreversible blindness and vision loss worldwide.
Imbalanced nutrients play important roles in the pathogenesis and pathophysiology of …

A translational in vivo and in vitro metabolomic study reveals altered metabolic pathways in red blood cells of type 2 diabetes

M Palomino-Schätzlein, R Lamas-Domingo… - Journal of clinical …, 2020 - mdpi.com
Clinical parameters used in type 2 diabetes mellitus (T2D) diagnosis and monitoring such as
glycosylated haemoglobin (HbA1c) are often unable to capture important information related …