All eukaryotic cells contain four RNA polymerases originally defined by their sensitivity to
different drugs, and now by the sets of genes they transcribe. 1− 4 Polymerase I produces …

Matrix attachment regions (MARs) are operationally defined as DNA elements that bind
specifically to the nuclear matrix in vitro. It is possible, although unproven, that they also …

The transcriptional machinery is thought to dissociate from DNA during replication. Certain
proteins, termed epigenetic marks, must be transferred from parent to daughter DNA strands …

The reference sequence for each human chromosome provides the framework for
understanding genome function, variation and evolution. Here we report the finished …

Biophysicists are modeling conformations of interphase chromosomes, often basing the
strengths of interactions between segments distant on the genetic map on contact …

We report the genome-wide mapping of ORC1 binding sites in mammals, by chromatin
immunoprecipitation and parallel sequencing (ChIP-seq). ORC1 binding sites in HeLa cells …

Microscopy shows that individual sites of DNA replication and transcription of mammalian
nuclei segregate into sets of roughly 22 and 16 higher order domains, respectively. Each …

The primary target for DNA methylation in mammalian genomes is cytosine in the
dinucleotide CpG. High densities of CpG dinucleotides are found in CpG islands, but …

Specific interactions of chromatin with the nuclear envelope (NE) in early embryos of
Drosophila melanogaster have been mapped and analyzed. Using fluorescence in situ …

As the relationship between nuclear structure and function begins to unfold, a picture is
emerging of a dynamic landscape that is centred on the two main processes that execute the …