Characterization of the zebrafish cell landscape at single-cell resolution
Zebrafish have been found to be a premier model organism in biological and regeneration
research. However, the comprehensive cell compositions and molecular dynamics during …
research. However, the comprehensive cell compositions and molecular dynamics during …
The power of zebrafish models for understanding the co‐occurrence of craniofacial and limb disorders
BT Truong, KB Artinger - Genesis, 2021 - Wiley Online Library
Craniofacial and limb defects are two of the most common congenital anomalies in the
general population. Interestingly, these defects are not mutually exclusive. Many patients …
general population. Interestingly, these defects are not mutually exclusive. Many patients …
Quis custodiet ipsos custodes (who controls the controllers)? Two decades of studies on HDAC9
Understanding how an epigenetic regulator drives different cellular responses can be a
tricky task. Very often, their activities are modulated by large multiprotein complexes, the …
tricky task. Very often, their activities are modulated by large multiprotein complexes, the …
A GWAS in Latin Americans identifies novel face shape loci, implicating VPS13B and a Denisovan introgressed region in facial variation
To characterize the genetic basis of facial features in Latin Americans, we performed a
genome-wide association study (GWAS) of more than 6000 individuals using 59 landmark …
genome-wide association study (GWAS) of more than 6000 individuals using 59 landmark …
Convergent and lineage-specific genomic differences in limb regulatory elements in limbless reptile lineages
Loss of limbs evolved many times in squamate reptiles. Here we investigated the genomic
basis of convergent limb loss in reptiles. We sequenced the genomes of a closely related …
basis of convergent limb loss in reptiles. We sequenced the genomes of a closely related …
The regulatory landscape of early maize inflorescence development
Background The functional genome of agronomically important plant species remains
largely unexplored, yet presents a virtually untapped resource for targeted crop …
largely unexplored, yet presents a virtually untapped resource for targeted crop …
An intronic enhancer of Cebpa regulates adipocyte differentiation and adipose tissue development via long‐range loop formation
X Li, S Zeng, L Chen, Y Zhang, X Li, B Zhang… - Cell …, 2024 - Wiley Online Library
Cebpa is a master transcription factor gene for adipogenesis. However, the mechanisms of
enhancer–promoter chromatin interactions controlling Cebpa transcriptional regulation …
enhancer–promoter chromatin interactions controlling Cebpa transcriptional regulation …
Identification of enhancers responsible for the coordinated expression of myosin heavy chain isoforms in skeletal muscle
K Long, D Su, X Li, H Li, S Zeng, Y Zhang, Z Zhong… - BMC genomics, 2022 - Springer
Background Skeletal muscles consist of fibers of differing contractility and metabolic
properties, which are primarily determined by the content of myosin heavy chain (MYH) …
properties, which are primarily determined by the content of myosin heavy chain (MYH) …
Developmental regulation of conserved non-coding element evolution provides insights into limb loss in squamates
Limb loss shows recurrent phenotypic evolution across squamate lineages. Here, based on
three de novo-assembled genomes of limbless lizards from different lineages, we showed …
three de novo-assembled genomes of limbless lizards from different lineages, we showed …
Convergent degenerated regulatory elements associated with limb loss in limbless amphibians and reptiles
C Zhu, S Li, D Zhang, J Zhang, G Wang… - Molecular Biology …, 2024 - academic.oup.com
Limbs are a defining characteristic of tetrapods, yet numerous taxa, primarily among
amphibians and reptiles, have independently lost limbs as an adaptation to new ecological …
amphibians and reptiles, have independently lost limbs as an adaptation to new ecological …