Biophysical cues, such as mechanical properties, play a critical role in tissue growth and
homeostasis. During organ development and tissue injury repair, compressive and tensional …

Insulin-like growth factors (IGFs) play important roles in mammalian growth, development,
aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and …

Increased extracellular matrix (ECM) stiffness and metabolic reprogramming of cancer cells
are two fundamental mediators of tumor progression, including hepatocellular carcinoma …

One of the hallmarks of cancer progression is strong drug resistance during clinical
treatments. The tumor microenvironment is closely associated with multidrug resistance, the …

Simple Summary The Hippo pathway is crucial for regulating cell growth, organ size, and
tissue regeneration. When this pathway goes awry, it can lead to uncontrolled cell growth …

In mammals, mechanics at multiple stages—nucleus to cell to ECM—underlie multiple
physiological and pathological functions from its development to reproduction to death …

While much work has been done in the design of biomaterials to control integrin‐mediated
adhesion, less emphasis has been put on functionalization of materials with cadherin …

Epithelial–mesenchymal transition (EMT) mediated by fluid shear stress (FSS) in the tumor
microenvironment plays an important role in driving metastasis of the malignant tumor. As a …

Osteoporosis is a common bone and metabolic disease that is characterized by bone
density loss and microstructural degeneration. Human bone marrow-derived mesenchymal …

Immune evasion—a well-established cancer hallmark—is a major barrier to immunotherapy
efficacy. While the molecular mechanisms and biological consequences underpinning …