[HTML][HTML] Mechanoregulation of YAP and TAZ in cellular homeostasis and disease progression
Biophysical cues, such as mechanical properties, play a critical role in tissue growth and
homeostasis. During organ development and tissue injury repair, compressive and tensional …
homeostasis. During organ development and tissue injury repair, compressive and tensional …
[HTML][HTML] Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapy
H Hua, Q Kong, J Yin, J Zhang, Y Jiang - Journal of hematology & …, 2020 - Springer
Insulin-like growth factors (IGFs) play important roles in mammalian growth, development,
aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and …
aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and …
[HTML][HTML] Stiffer matrix accelerates migration of hepatocellular carcinoma cells through enhanced aerobic glycolysis via the MAPK-YAP signaling
QP Liu, Q Luo, B Deng, Y Ju, GB Song - Cancers, 2020 - mdpi.com
Increased extracellular matrix (ECM) stiffness and metabolic reprogramming of cancer cells
are two fundamental mediators of tumor progression, including hepatocellular carcinoma …
are two fundamental mediators of tumor progression, including hepatocellular carcinoma …
[HTML][HTML] Matrix stiffness modulates ILK-mediated YAP activation to control the drug resistance of breast cancer cells
X Qin, X Lv, P Li, R Yang, Q Xia, Y Chen, Y Peng… - … et Biophysica Acta (BBA …, 2020 - Elsevier
One of the hallmarks of cancer progression is strong drug resistance during clinical
treatments. The tumor microenvironment is closely associated with multidrug resistance, the …
treatments. The tumor microenvironment is closely associated with multidrug resistance, the …
[HTML][HTML] New insights into YAP/TAZ-TEAD-mediated gene regulation and biological processes in cancer
Simple Summary The Hippo pathway is crucial for regulating cell growth, organ size, and
tissue regeneration. When this pathway goes awry, it can lead to uncontrolled cell growth …
tissue regeneration. When this pathway goes awry, it can lead to uncontrolled cell growth …
Progress in the mechanical modulation of cell functions in tissue engineering
In mammals, mechanics at multiple stages—nucleus to cell to ECM—underlie multiple
physiological and pathological functions from its development to reproduction to death …
physiological and pathological functions from its development to reproduction to death …
You talking to me? Cadherin and integrin crosstalk in biomaterial design
E Barcelona‐Estaje, MJ Dalby… - Advanced …, 2021 - Wiley Online Library
While much work has been done in the design of biomaterials to control integrin‐mediated
adhesion, less emphasis has been put on functionalization of materials with cadherin …
adhesion, less emphasis has been put on functionalization of materials with cadherin …
Fluid shear stress activates YAP to promote epithelial–mesenchymal transition in hepatocellular carcinoma
Epithelial–mesenchymal transition (EMT) mediated by fluid shear stress (FSS) in the tumor
microenvironment plays an important role in driving metastasis of the malignant tumor. As a …
microenvironment plays an important role in driving metastasis of the malignant tumor. As a …
[HTML][HTML] Notch signaling and fluid shear stress in regulating osteogenic differentiation
Osteoporosis is a common bone and metabolic disease that is characterized by bone
density loss and microstructural degeneration. Human bone marrow-derived mesenchymal …
density loss and microstructural degeneration. Human bone marrow-derived mesenchymal …
[HTML][HTML] Do tumor mechanical stresses promote cancer immune escape?
Immune evasion—a well-established cancer hallmark—is a major barrier to immunotherapy
efficacy. While the molecular mechanisms and biological consequences underpinning …
efficacy. While the molecular mechanisms and biological consequences underpinning …