Chagas cardiomyopathy: an update of current clinical knowledge and management: a scientific statement from the American Heart Association

MCP Nunes, A Beaton, H Acquatella, C Bern… - Circulation, 2018 - Am Heart Assoc
Background: Chagas disease, resulting from the protozoan Trypanosoma cruzi, is an
important cause of heart failure, stroke, arrhythmia, and sudden death. Traditionally …

Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity

B Zingales - Acta tropica, 2018 - Elsevier
The genetic diversity of Trypanosoma cruzi, the protozoan agent of Chagas disease, is
widely recognized. At present, T. cruzi is partitioned into seven discrete typing units (DTUs) …

Pathology and pathogenesis of Chagas heart disease

KM Bonney, DJ Luthringer, SA Kim… - Annual Review of …, 2019 - annualreviews.org
Chagas heart disease is an inflammatory cardiomyopathy that develops in approximately
one-third of people infected with the protozoan parasite Trypanosoma cruzi. One way T …

Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection

ALSS de Andrade, F Zicker, RM de Oliveira, SA e Silva… - The Lancet, 1996 - thelancet.com
Background Benznidazole, a nitroimidazole derivative, has been recommended for the
treatment of acute and congenital Trypanosoma cruzi infection (Chagas' disease). We have …

[PDF][PDF] Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' disease.

S Sosa Estani, EL Segura, AM Ruiz… - The American journal …, 1998 - academia.edu
A double-blind, randomized, clinical field trial was designed to test the efficacy and tolerance
of a specific drug treatment in children in the indeterminate phase of infection by …

[HTML][HTML] Current understanding of immunity to Trypanosoma cruzi infection and pathogenesis of Chagas disease

FS Machado, WO Dutra, L Esper, KJ Gollob… - Seminars in …, 2012 - Springer
Chagas disease caused by Trypanosoma cruzi remains an important neglected tropical
disease and a cause of significant morbidity and mortality. No longer confined to endemic …

Recent clinical trials for the etiological treatment of chronic Chagas disease: advances, challenges and perspectives

JA Urbina - Journal of Eukaryotic Microbiology, 2015 - Wiley Online Library
Chagas disease, a chronic systemic parasitosis caused by the Kinetoplastid protozoon
Trypanosoma cruzi, is the first cause of cardiac morbidity and mortality in poor rural and …

[HTML][HTML] Long term evaluation of etiological treatment of Chagas disease with benznidazole

JR Cançado - Revista do Instituto de Medicina Tropical de Sao Paulo, 2002 - SciELO Brasil
The aim of this article is to present an investigation of cure rate, after long follow up, of
specific chemotherapy with benznidazole in patients with both acute and chronic Chagas …

Congenital Chagas' disease: diagnostic and clinical aspects

H Freilij, J Altcheh - Clinical Infectious Diseases, 1995 - academic.oup.com
The diagnostic and clinical aspects of congenital Chagas' disease were studied in 71
children in Buenos Aires. The children's ages ranged from 2 days to 10 years. In infants< 6 …

[PDF][PDF] Use of a Simplified Polymerase Chain Reaction Procedure to Detect Trypanosoma cruzi in Blood Samples from Chronic Chagasic Patients in a Rural Endemic …

P Wincker, C Britto, JB Pereira… - The American Journal …, 1994 - researchgate.net
USE OF A SIMPLIFIED POLYMERASE CHAIN REACTION PROCEDURE TO DETECT
TRYPANOSOMA CRUZI IN BLOOD SAMPLES FROM CHRONIC CHAGASIC PATIE Page 1 Am. J …